Plasma Amino Acid Concentration under Human Growth Hormone Treatment in Uremic Children

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Abstract

The plasma amino acid concentrations were investigated before and after 3 and 30 months of human recombinant growth hormone treatment in 7 children with chronic renal failure. The concentrations of amino acids in plasma showed characteristic changes (pretreatment vs. after 3 and 30 months of treatment): Lys 113 ± 33 vs. 162 ± 27 and 109 ± 38 μmol/l, Met 21 ± 8 vs. 31 ± 4 and 16 ± 5, Thrl05 ± 23 vs. 148 ± 60 and 118 ± 30, Ala 455 ± 109 vs. 536 ± 93 and 314 ± 60, Gin 298 ± 66 vs. 277 ± 52 and 544 ± 65, Glu 168 ± 46 vs. 209 ± 57 and 96 ± 24, Gly345 ± 137 vs. 479 ± 169 and 342 ± 95, Pro 378 ± 148 vs. 422 ± 28 and 527 ± 229, OH-Pro 33 ± 17 vs. 105 ± 23 and 97 ± 35, Se 133 ± 39 vs. 178 ± 55 and 131 ± 12 μmol/l. Long-term treatment with human recombinant growth hormone normalized plasma alanine, glutamine, and glutamic acid levels, increased the OH-Pro concentration, and did not alter the amino acid ratios of Gly/Val, Phe/Tyr, Ser/Gly, and Asn/Asp, but the Gln/Glu ratio approached the normal value.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1995

Publication date (Print): 1995

Publication date (Electronic): 05 December 2008

Volume: 44

Issue: 6

Pages: 265-267

Affiliations

First Department of Paediatrics, ^aSemmelweis University Medical School and ^bPostgraduate Medical School, Budapest, Hungary

Article

Publisher ID: 184638 Other ID: Horm Res 1995;44:265–267

DOI: 10.1159/000184638

PubMed ID: 8808011

SO-VID: bcc3afad-398b-4bdf-a00b-dc8dd11ff87a

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 13 October 1994

Date accepted : 18 July 1995

Page count

Pages: 3

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