Deficits in cortical, diencephalic and midbrain gray matter in alcoholism measured by VBM: Effects of co-morbid substance abuse ^{☆ ☆☆ ★}

Abstract

Objective

Alcoholism has been associated with a widespread pattern of gray matter atrophy. This study sought to investigate the spectrum of volume alterations in a population of alcoholics with only alcohol dependence, polysubstance abusing alcoholics, and a comparison population of healthy controls.

Method

Thirty-seven ‘pure’ alcoholics, 93 polysubstance abusing alcoholics, and 69 healthy controls underwent structural T1 MRI scans. Voxel-based morphometry was performed to investigate gray matter alterations.

Results

Alcoholic dependent inpatients (both with and without a history of DSM-IV substance abuse/dependence diagnosis) displayed significant gray matter differences in the mesial region of the frontal lobe and right temporal lobe. ‘Pure’ alcoholics exhibited a pattern of subcortical changes similar to that seen in Wernicke–Korsakoff Syndrome when compared to polysubstance abusing alcoholics. ‘Pure’ alcoholics and polysubstance abusing alcoholics did not differ significantly in measures of cortical gray matter, liver function, or nutrition.

Conclusions

These findings reinforce the accepted literature in regards to frontal lobe gray matter atrophy in alcohol dependence. This study calls for additional research in order to investigate the spectrum from uncomplicated alcoholism to Wernicke–Korsakoff Syndrome. Further research is needed to elucidate the exact cause of this pattern of differences and to determine what factors are responsible for the patterns of gray matter reduction or difference in ‘pure’ and polysubstance abusing alcoholics.

Highlights

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  Large scale voxel-based morphometry study on alcoholics and healthy controls.

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  Alcoholics display less gray matter in the mesial frontal lobe and the temporal lobe.

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  “Pure” alcoholics show a pattern of deficit similar to that of Wernicke's Encephalopathy.