For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
32
views
70
references
 Top references
cited by
15
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      310
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Understanding the fundamental steps of virus life cycles including virus–host interactions is essential for the design of effective antiviral strategies. Such understanding has been deferred by the complexity of higher eukaryotic host organisms. To circumvent experimental difficulties associated with this, systems were developed to replicate viruses in the yeast Saccharomyces cerevisiae. The systems include viruses with RNA and DNA genomes that infect plants, animals and humans. By using the powerful methodologies available for yeast genetic analysis, fundamental processes occurring during virus replication have been brought to light. Here, we review the different viruses able to direct replication and gene expression in yeast and discuss their main contributions in the understanding of virus biology.

          Related collections

          Most cited references70

          • Record: found
          • Abstract: found
          • Article: not found

          Induction and suppression of RNA silencing by an animal virus.

          Hongwei Li, Wan Xiang Li, Shou Ding (2002)
          RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.
          Article 0 comments Cited 180 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Systematic screen for human disease genes in yeast.

            Lars M. Steinmetz, Curt Scharfe, Adam Deutschbauer … (2002)
            High similarity between yeast and human mitochondria allows functional genomic study of Saccharomyces cerevisiae to be used to identify human genes involved in disease. So far, 102 heritable disorders have been attributed to defects in a quarter of the known nuclear-encoded mitochondrial proteins in humans. Many mitochondrial diseases remain unexplained, however, in part because only 40-60% of the presumed 700-1,000 proteins involved in mitochondrial function and biogenesis have been identified. Here we apply a systematic functional screen using the pre-existing whole-genome pool of yeast deletion mutants to identify mitochondrial proteins. Three million measurements of strain fitness identified 466 genes whose deletions impaired mitochondrial respiration, of which 265 were new. Our approach gave higher selection than other systematic approaches, including fivefold greater selection than gene expression analysis. To apply these advantages to human disorders involving mitochondria, human orthologs were identified and linked to heritable diseases using genomic map positions.
            Article 0 comments Cited 159 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Synthesis and assembly of hepatitis B virus surface antigen particles in yeast.

              Luis A Medina, Marla B. Hall, P Valenzuela … (1982)
              The surface antigens of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5'-flanking region of yeast alcohol dehydrogenase I as a promotor to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.
              Article 0 comments Cited 124 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Juana Díez
                Journal
                Journal ID (nlm-ta): Virus Res
                Journal ID (iso-abbrev): Virus Res
                Title: Virus Research
                Publisher: Elsevier B.V.
                ISSN (Print): 0168-1702
                ISSN (Electronic): 1872-7492
                Publication date PMC-release: 15 May 2006
                Publication date (Print): September 2006
                Publication date (Electronic): 15 May 2006
                Volume: 120
                Issue: 1
                Pages: 49-56
                Affiliations
                [a ]Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
                [b ]Department of Virology, University of the Saarland, Homburg, Germany
                Author notes
                [* ]Corresponding author. Tel.: +34 93 542 2887; fax: +34 93 542 2802. juana.diez@ 123456upf.edu
                Article
                Publisher ID: S0168-1702(05)00357-6
                DOI: 10.1016/j.virusres.2005.11.018
                PMC ID: 7114155
                PubMed ID: 16698107
                SO-VID: bcf8ac35-1f68-412c-96de-29e45c428889
                Copyright statement: Copyright © 2005 Elsevier B.V. All rights reserved.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Date received : 19 August 2005
                Date revision received : 16 November 2005
                Date accepted : 21 November 2005
                Categories
                Subject: Article

                ScienceOpen disciplines: Microbiology & Virology
                Keywords: bromovirus,tombusvirus,nodavirus,papillomavirus,viral replication,yeast
                Data availability:
                ScienceOpen disciplines: Microbiology & Virology
                Keywords: bromovirus, tombusvirus, nodavirus, papillomavirus, viral replication, yeast

                Comments

                Comment on this article

                scite_

                Similar content310

                See all similar

                Cited by13

                See all cited by

                Most referenced authors2,676

                See all reference authors