Background. To study whether weaker self-esteem in adolescence is connected with smoking behavior in adulthood. Methods. An age cohort born in 1979 responded to the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the age of 16 ( n = 1,072). Respondents' smoking behavior was monitored annually during adolescence and 75.3% ( n = 813) of them remained nonsmokers during adolescence. A follow-up questionnaire eliciting smoking behavior was sent to the adolescent nonsmokers at the age of 29 years. Response rate at follow-up was 46.2% ( n = 376). Results. Weaker self-esteem (LAWSEQ score ≥ 3) during the adolescence was not significantly associated with smoking in adulthood. However, those respondents who had weaker self-esteem in adolescence had increased risk of having been smoking regularly (adjusted OR 1.8, 95% CI 1.1–3.0) although not all of them were smokers at the time of the follow-up. Conclusions. Those with weaker self-esteem in adolescence are more likely to smoke regularly in adulthood.