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      Serum antibodies against Panton-Valentine leukocidin in a normal population and during Staphylococcus aureus infection.

      Clinical Microbiology and Infection

      Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Bacterial, blood, Bacterial Toxins, immunology, Child, Child, Preschool, Exotoxins, Humans, Infant, Infant, Newborn, Leukocidins, Middle Aged, Serum, Staphylococcal Infections, Staphylococcus aureus, Young Adult

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          Abstract

          To determine whether Staphylococcus aureus Panton-Valentine leukocidin (PVL) is expressed during human infection, anti-PVL antibody titres were compared in patients with PVL-positive and PVL-negative staphylococcal infections, and in patients with no evidence of S. aureus infection. Patients with PVL-positive strains had higher levels of anti-PVL antibodies than individuals of both control groups. The median anti-PVL titre increased 8.6-fold during the course of PVL-positive infection and 1.4-fold during PVL-negative infection. These results indicate that only PVL-positive S. aureus strains elicit significant anti-PVL antibody production in humans, and demonstrate the production of PVL during PVL-positive S. aureus infection. The protective role of this immune response remains to be established.

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          Journal
          19154491
          10.1111/j.1469-0691.2008.02650.x

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