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Sodium restriction potentiates the renoprotective effects of combined vitamin D receptor activation and angiotensin-converting enzyme inhibition in established proteinuric nephropathy
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Abstract
Renin-angiotensin-aldosterone system (RAAS) blockade provides renoprotective effects
in chronic kidney disease (CKD); yet progressive renal function loss remains common.
Dietary sodium restriction potentiates the renoprotective effects of RAAS blockade.
Vitamin D receptor activator (VDRA) treatment reduces proteinuria, inflammation and
fibrosis, but whether these effects depend on sodium intake has not been studied.
We hypothesized that the renoprotective effects of VDRA treatment, with or without
RAAS blockade, are modulated by sodium intake.