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      Health Economics of Dengue: A Systematic Literature Review and Expert Panel's Assessment

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          Abstract

          Dengue vaccines are currently in development and policymakers need appropriate economic studies to determine their potential financial and public health impact. We searched five databases (PubMed, EMBASE, LILAC, EconLit, and WHOLIS) to identify health economics studies of dengue. Forty-three manuscripts were identified that provided primary data: 32 report economic burden of dengue and nine are comparative economic analyses assessing various interventions. The remaining two were a willingness-to-pay study and a policymaker survey. An expert panel reviewed the existing dengue economic literature and recommended future research to fill information gaps. Although dengue is an important vector-borne disease, the economic literature is relatively sparse and results have often been conflicting because of use of inconsistent assumptions. Health economic research specific to dengue is urgently needed to ensure informed decision making on the various options for controlling and preventing this disease.

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          Dengue/dengue hemorrhagic fever: the emergence of a global health problem.

          D J Gubler, G G Clark (1995)
          Article 0 comments Cited 190 times – based on 0 reviews     Review now
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            The economic impact of pandemic influenza in the United States: priorities for intervention.

            M. Meltzer, N Cox, K. Fukuda (1999)
            We estimated the possible effects of the next influenza pandemic in the United States and analyzed the economic impact of vaccine-based interventions. Using death rates, hospitalization data, and outpatient visits, we estimated 89,000 to 207,000 deaths; 314,000 to 734,000 hospitalizations; 18 to 42 million outpatient visits; and 20 to 47 million additional illnesses. Patients at high risk (15% of the population) would account for approximately 84% of all deaths. The estimated economic impact would be US$71.3 to $166.5 billion, excluding disruptions to commerce and society. At $21 per vaccinee, we project a net savings to society if persons in all age groups are vaccinated. At $62 per vaccinee and at gross attack rates of 25%, we project net losses if persons not at high risk for complications are vaccinated. Vaccinating 60% of the population would generate the highest economic returns but may not be possible within the time required for vaccine effectiveness, especially if two doses of vaccine are required.
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              Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand.

              T Endy (2002)
              Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the world. Knowledge about the epidemiology and host determinants of inapparent and severe dengue virus infections is limited. In this paper, the authors report findings from the first 3 years of a prospective study of dengue virus transmission and disease severity conducted in a cohort of 2,119 elementary school children in northern Thailand. A total of 717,106 person-school days were observed from 1998 to 2000. The incidence of inapparent and of symptomatic dengue virus infection was 4.3% and 3.6% in 1998, 3.2% and 3.3% in 1999, and 1.4% and 0.8% in 2000, respectively. Symptomatic dengue virus infection was responsible for 3.2%, 7.1%, and 1.1% of acute-illness school absences in 1998, 1999, and 2000, respectively. The early symptom complex of acute dengue virus infection is protean and difficult to distinguish from other causes of febrile childhood illnesses. The authors' results illustrate the spatial and temporal diversity of dengue virus infection and the burden of dengue disease in schoolchildren in Thailand. Their findings increase understanding of dengue virus transmission and disease severity in a well-defined cohort population and offer a study design in which to test the efficacy of potential dengue vaccines.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Am J Trop Med Hyg
                Journal ID (publisher-id): tpmd
                Title: The American Journal of Tropical Medicine and Hygiene
                Publisher: The American Society of Tropical Medicine and Hygiene
                ISSN (Print): 0002-9637
                ISSN (Electronic): 1476-1645
                Publication date (Print): 04 March 2011
                Publication date PMC-release: 04 March 2011
                Volume: 84
                Issue: 3
                Pages: 473-488
                Affiliations
                Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Republic of Korea; Centre for Health Economics Research and Modeling Infectious Diseases, Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium; Centers for Disease Control and Prevention, Atlanta, Georgia; Heller School, Brandeis University, Waltham, Massachusetts; Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland; GlaxoSmithKline Biologicals, Wavre, Belgium; Sanofi Pasteur, Lyon, France; Université Catholique de Lille, Lille, France
                Author notes
                *Address correspondence to Mark E. Beatty, International Vaccine Institute San 4-8 Bongcheon-7-dong, Kwanak-gu, Seoul, Korea. E-mail: mbeatty@ 123456pdvi.org
                Article
                DOI: 10.4269/ajtmh.2011.10-0521
                PMC ID: 3042827
                PubMed ID: 21363989
                SO-VID: bd2edf53-c311-4f63-9c7d-e482a9e6dafd
                Copyright © ©The American Society of Tropical Medicine and Hygiene
                License:

                This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 20 September 2010
                Date accepted : 16 December 2010
                Categories
                Subject: Articles

                ScienceOpen disciplines: Infectious disease & Microbiology
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                ScienceOpen disciplines: Infectious disease & Microbiology

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