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      Japanese cedar pollinosis and HLA-DP5

      , , , , , ,
      Tissue Antigens
      Wiley

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          Abstract

          Japanese cedar pollinosis is a type I allergic disease caused by Japanese cedar (Cryptomeria japonica) pollen. We investigated the association between the disease and HLA class II alleles by HLA-DNA typing using a PCR-SSOP method and found that the frequency of HLA-DP5 (DPA1*02022 and DPB1*0501) was significantly increased in the patients. To investigate whether the HLA-DP5 molecule is directly involved in the pathogenesis of the disease, Japanese cedar pollen antigen (CPAg)-specific T cell lines were established from 3 patients who possessed HLA-DP5 (DPA1*02022/ DPB1*0501). By using these CPAg-specific T cell lines and HLA class II-expressing L-cell transfectants, we found that disease-associated HLA-DP5 restricted T cells specific for CPAg existed in the patients. Furthermore, among 38 synthesized overlapping peptides spanning the entire length of one of the major Japanese cedar pollen allergens, Cry j 1, an immunodominant peptide which induced HLA-DP5 restricted Th2 was identified. These observations suggest that the HLA-DP5 may be involved, at least in part, in the pathogenesis, by helping the IgE antibody production against CPAg.

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          Author and article information

          Journal
          TAN
          Tissue Antigens
          Wiley
          00012815
          13990039
          June 1996
          June 1996
          : 47
          : 6
          : 485-491
          Article
          10.1111/j.1399-0039.1996.tb02590.x
          8813737
          bd312e27-8ddd-402c-a9b4-7e4eeac32413
          © 1996

          http://doi.wiley.com/10.1002/tdm_license_1.1

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