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      Enhancement of canthaxanthin production from Dietzia natronolimnaea HS-1 in a fed-batch process using trace elements and statistical methods

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          Abstract

          Under fed-batch process conditions, the statistical analysis of trace elements was performed by application of Plackett-Burman design (for screening tests) and response surface methodology (for predicting the optimal points) to achieve the highest level of canthaxanthin production from Dietzia natronolimnaea HS-1. Plackett-Burman design was conducted on eleven trace elements (i. e., aluminum, boron, cobalt, copper, iron, magnesium, manganese, molybdenum, selenium, vanadium and zinc) to select out elements that significantly enhance the canthaxanthin production of D. natronolimnaea HS-1. Plackett-Burman design revealed that Fe3+, Cu2+ and Zn2+ ions had the highest effect on canthaxanthin production of D. natronolimnaea HS-1 (P<0.05). These three elements were used for further optimization. By means of response surface methodology for the fed-batch process, the optimum conditions to achieve the highest level of canthaxanthin (8923±18 µg/L) were determined as follow: Fe3+ 30 ppm, Cu2+ 28.75 ppm and Zn2+ 27 ppm.

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          Most cited references50

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          The Biochemistry of the Carotenoids

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            Environmental and cultural stimulants in the production of carotenoids from microorganisms.

            P. Bhosale (2004)
            Commercial production of carotenoids from microorganisms competes mainly with synthetic manufacture by chemical procedures. Efficient stimulation of carotenoid biosynthesis is expected to promote accumulation of carotenoid by microbes. This review describes the variety of environmental and cultural stimulants studied during the last few decades which enhance volumetric production and cellular accumulation of commercially important carotenoids from microalgae, fungi and bacteria. Stimulation of carotenoid production by white-light illumination and temperature fluctuation is discussed along with supplementation of metal ions, salts, organic solvents, preformed precursors and several other chemicals in the culture broth. Reports on the improvements in yield are reviewed and assessed from a biotechnology point of view.
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              Carotenoid biosynthesis in microorganisms and plants.

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Journal
                bjce
                Brazilian Journal of Chemical Engineering
                Braz. J. Chem. Eng.
                Brazilian Society of Chemical Engineering (São Paulo )
                0104-6632
                December 2010
                : 27
                : 4
                : 517-529
                Affiliations
                [1 ] University of Tehran Iran
                Article
                S0104-66322010000400003
                10.1590/S0104-66322010000400003
                bd4eca82-38be-447d-ade2-6910e8315343

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0104-6632&lng=en
                Categories
                ENGINEERING, CHEMICAL

                General engineering
                Canthaxanthin,Fed-batch process,Trace elements,Dietzia natronolimnaea HS-1,Statistical designs

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