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      Effect of Dextran Infusion on Left Atrial Size in Normal Subjects

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          Abstract

          The purpose of this study was to evaluate left atrium dimension during acute volume loading. Low molecular weight dextran solution (1,000 ml) was continuously infused in 10 subjects without cardiac disease. Measurements of pulmonary arterial, capillary wedge, right atrial and systemic blood pressures, cardiac output, heart rate and M-mode left atrial maximum diameter were made in basal conditions and after 250, 500, 750 and 1,000 ml of dextran. In 4 subjects a two-dimensional echocardiogram was also obtained in the short axis and four-chamber views. Dextran produced the following changes (mean values ± standard deviation) in haemodynamic variables: right atrial and wedge pressures increased from 3.2 ± 1.55 to 12.3 ± 3.08 mm Hg (p < 0.001) and from 6.9 ± 1.45 to 20.6 ± 3.44 mm Hg (p < 0.001), respectively. Stroke volume increased from 70.5 ± 31.6 to 86.6 ± 24.6 ml/beat (p < 0.05). Heart rate increased from 81.0 ± 15.8 to 95.0 ± 12.3 beats/min (p < 0.05). Left atrial maximum diameter showed a slight incrase after 500 ml of dextran (from 39.5 ± 4.1 to 43.6 ± 5.0 mm, p < 0.05). It did not further increase by continuing the infusion up to 1,000 ml despite the marked increase in wedge pressure. The results show that left atrial size is partly independent of haemodynamic changes and that the compliance of the left atrium is relatively low. This finding is consistent with the common clinical observation that the left atrium is only slightly enlarged in acute mitral insufficiency.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1982
          1982
          07 November 2008
          : 69
          : 5
          : 257-264
          Affiliations
          Cardiology Unit, University of Florence, Italy
          Article
          173514 Cardiology 1982;69:257–264
          10.1159/000173514
          6184163
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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