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Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH-GRID Study.

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      Abstract

      Apelin is an adipokine directly associated with adiposity, insulin resistance, and decreased blood pressure. Urinary 8-isoprostane is a marker of chronic oxidative endothelial stress. Visfatin, an adipokine that acts by binding and activating the insulin receptor, has been associated with hypertension. As severe hypertension (SH) is highly prevalent among African Americans (AA), we aimed to assess the association of these biomarkers with SH status.

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      Affiliations
      [1 ] Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana, USA;
      [2 ] Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA;
      [3 ] National Human Genome Research Institute, Bethesda, Maryland, USA;
      [4 ] NIH/National Heart Lung and Blood Institute, Bethesda, Maryland, USA.
      [5 ] Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana, USA; abidules@indiana.edu.
      Journal
      Am. J. Hypertens.
      American journal of hypertension
      Oxford University Press (OUP)
      1941-7225
      0895-7061
      July 2016
      : 29
      : 7
      26869250 hpw007 10.1093/ajh/hpw007 5863771

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