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      Nuclear Receptors, RXR, and the Big Bang.

      1 , 2
      Cell
      Elsevier BV

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          Abstract

          Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan receptors. Characterization of these orphan receptors and, in particular, of the retinoid X receptor (RXR) positioned nuclear receptors at the epicenter of the "Big Bang" of molecular endocrinology. This Review provides a personal perspective on nuclear receptors and explores their integrated and coordinated signaling networks that are essential for multicellular life, highlighting the RXR heterodimer and its associated ligands and transcriptional mechanism.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          Mar 27 2014
          : 157
          : 1
          Affiliations
          [1 ] Howard Hughes Medical Institute; The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.
          [2 ] Howard Hughes Medical Institute; The Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: davo.mango@utsouthwestern.edu.
          Article
          S0092-8674(14)00346-8 NIHMS578607
          10.1016/j.cell.2014.03.012
          4029515
          24679540
          bd60cede-fe17-4297-956a-192efd31de56
          Copyright © 2014 Elsevier Inc. All rights reserved.
          History

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