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Abstract
A criticism of the use of the rabbit low-volume eye test to determine eye irritation
hazard for man is the lack of comparative data in man and rabbit with undiluted products.
To address this, such a study has been performed in man and rabbit using undiluted
model liquid detergents. The hypothesis tested was that if, under identical test conditions,
the effects in the rabbit were the same or greater than the response in man, then
it is valid to use the low-volume eye test to assess eye irritation hazard for man.
The studies were carried out using 29 human volunteers and 12 rabbits. The effects
in the rabbit were unequivocally greater than the effects observed in man, but clearly
less than the expected response from these types of product in the Draize test. The
results from this study confirm the sensitivity of the rabbit as a test species, and
support the use of the low-volume eye test to assess eye irritation hazard for man.
Any in vitro/ex vivo alternative to assess eye irritation should be developed against
the rabbit low-volume eye test or human data where available.