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      Evaluation of V maxTP as an Index of Myocardial Contractility during Afterload and Preload Elevations

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          Abstract

          In order to test if the maximal velocity of shortening (V<sub>max</sub> TP) reflects the level of inotropism and is affected by preload and afterload, the behavior of this index was compared in two groups of anesthetized, atropinized dogs when preload and afterload were raised with an angiotensin II infusion. In seven dogs (group I), the arterial pressure elevation was allowed to inhibit reflectively the sympathetic tone and depress contractility. In eleven dogs (group II), the adrenergic activity was abolished by previous administration of reserpine. In group I, there was a significant decrease in V<sub>max</sub> TP during the angiotensin infusion. In group II, there was no significant change in the value of this index when the drug was infused. In six animals of this group, a further increase of arterial pressure was induced, but the values of V<sub>maχ</sub>TP remained similar to control. These results suggest that this index reflects the inotropic state of the myocardium and does not suffer significantly from the influence of preload and afterload elevations within our experimental limits.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1976
          1976
          29 October 2008
          : 61
          : 3
          : 170-180
          Affiliations
          Faculdade de Ciências Médicas e Biológicas de Botucatu, SP, Brasil
          Article
          169760 Cardiology 1976;61:170–180
          10.1159/000169760
          1009542
          © 1976 S. Karger AG, Basel

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          Pages: 11
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