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      Cellulose-based hydrogel materials: chemistry, properties and their prospective applications


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          Hydrogels based on cellulose comprising many organic biopolymers including cellulose, chitin, and chitosan are the hydrophilic material, which can absorb and retain a huge proportion of water in the interstitial sites of their structures. These polymers feature many amazing properties such as responsiveness to pH, time, temperature, chemical species and biological conditions besides a very high-water absorption capacity. Biopolymer hydrogels can be manipulated and crafted for numerous applications leading to a tremendous boom in research during recent times in scientific communities. With the growing environmental concerns and an emergent demand, researchers throughout the globe are concentrating particularly on naturally derived hydrogels due to their biocompatibility, biodegradability and abundance. Cellulose-based hydrogels are considered as useful biocompatible materials to be used in medical devices to treat, augment or replace any tissue, organ, or help function of the body. These hydrogels also hold a great promise for applications in agricultural activity, as smart materials and some other useful industrial purposes. This review offers an overview of the recent and contemporary research regarding physiochemical properties of cellulose-based hydrogels along with their applications in multidisciplinary areas including biomedical fields such as drug delivery, tissue engineering and wound healing, healthcare and hygienic products as well as in agriculture, textiles and industrial applications as smart materials.

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          Most cited references189

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          Hydrogels for tissue engineering.

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            Hydrogels in pharmaceutical formulations.

            N. Peppas (2000)
            The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
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              Designing cell-compatible hydrogels for biomedical applications.

              Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. They can be engineered to resemble the extracellular environment of the body's tissues in ways that enable their use in medical implants, biosensors, and drug-delivery devices. Cell-compatible hydrogels are designed by using a strategy of coordinated control over physical properties and bioactivity to influence specific interactions with cellular systems, including spatial and temporal patterns of biochemical and biomechanical cues known to modulate cell behavior. Important new discoveries in stem cell research, cancer biology, and cellular morphogenesis have been realized with model hydrogel systems premised on these designs. Basic and clinical applications for hydrogels in cell therapy, tissue engineering, and biomedical research continue to drive design improvements using performance-based materials engineering paradigms.

                Author and article information

                12252847920 , mahin.tex.7393@gmail.com
                Prog Biomater
                Prog Biomater
                Progress in Biomaterials
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                4 September 2018
                4 September 2018
                September 2018
                : 7
                : 153-174
                [1 ]ISNI 0000 0001 0662 7451, GRID grid.64337.35, Department of Textiles, Apparel Design and Merchandising, , Louisiana State University, ; Baton Rouge, LA 70803 USA
                [2 ]ISNI 0000 0004 1936 738X, GRID grid.213876.9, Department of Textiles, Merchandising and Interiors, , University of Georgia, ; Athens, GA 30602 USA
                [3 ]ISNI 0000 0000 9744 3393, GRID grid.413089.7, College of Textile Engineering, , University of Chittagong, ; Chittagong, 4331 Bangladesh
                [4 ]ISNI 0000 0004 0443 8843, GRID grid.440505.0, Department of Textile Engineering, , Dhaka University of Engineering and Technology, DUET, ; Gazipur, 1700 Bangladesh
                [5 ]ISNI 0000 0004 0443 8843, GRID grid.440505.0, Department of Chemistry, , Dhaka University of Engineering and Technology, DUET, ; Gazipur, 1700 Bangladesh
                Author information
                © The Author(s) 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                : 6 June 2018
                : 25 August 2018
                Review Paper
                Custom metadata
                © The Author(s) 2018

                hydrogels,cellulose,chitin,chitosan,smart material,biomedical applications


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