Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence.

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Abstract

In the past 20 years, research and clinical trials on the healing process of chronic wounds have highlighted the key role of the family of enzymes called matrix metalloproteinases (MMPs). If a strong correlation between the course of healing of chronic wounds and the levels of a biological marker can be demonstrated, then it may be possible to: i) identify the best marker threshold to predict the clinical evolution of the pathology; and ii) if causality has been found between the marker and pathology, to improve the healing outcome, to change the marker level.

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Journal

Journal ID (iso-abbrev): J Wound Care

Title: Journal of wound care

Publisher: Mark Allen Group

ISSN: 0969-0700

ISSN (Print): 0969-0700

Publication date (Electronic): May 2016

Volume: 25

Issue: 5

Affiliations

[1 ] University Podiatry Clinic, College of Medicine, Complutense University, Madrid, Spain.

[2 ] Department of Systems Medicine - University of Tor Vergata - Roma, Italia.

[3 ] Rothschild University Hospital, APHP, Paris, France.

[4 ] Department of Surgery and Cancer, Faculty of Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, UK.

[5 ] Department of Endocrinology, Diabetology and Geriatrics - Klinikum Bürgerhospital, Stuttgart, Germany.

Article

DOI: 10.12968/jowc.2016.25.5.277

PubMed ID: 27169343

SO-VID: bd983b2b-266f-42ff-a316-ce16612bf36b

History

Keywords: chronic wound,matrix metalloproteinase,wound healing

Data availability:

Keywords: chronic wound, matrix metalloproteinase, wound healing

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