28
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic voltammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode. A simple and sensitive differential pulse voltammetry (DPV) technique was proposed for the direct quantitative determination of FA in Angelica sinensis and spiked human urine samples for the first time. The dependence of the intensities of currents and potentials on nature of the supporting electrolyte, pH, scan rate, and concentration was investigated. Under optimal conditions, the proposed sensor exhibited excellent electrochemical sensitivity to FA, and the oxidation peak current was proportional to FA concentration in the range of 8.95 × 10 −8 M ~5.29 × 10 −5 M, with a relatively low detection limit of 4.42 × 10 −8 M. This fabricated sensor also displayed acceptable reproducibility, long-term stability, and high selectivity with negligible interferences from common interfering species. Besides, it was applied to detect FA in Angelica sinensis and biological samples with satisfactory results, making it a potential alternative tool for the quantitative detection of FA in pharmaceutical analysis.

          Related collections

          Most cited references81

          • Record: found
          • Abstract: not found
          • Article: not found

          Graphene based materials: Past, present and future

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Graphene quantum dots-based platform for the fabrication of electrochemical biosensors

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A graphene oxide-based electrochemical sensor for sensitive determination of 4-nitrophenol.

              A graphene oxide (GO) film coated glassy carbon electrode (GCE) was fabricated for sensitive determination of 4-nitrophenol (4-NP). The GO-based sensor was characterized by scanning electron microscope, atomic force microscopy and electrochemical impedance spectroscopy. The electrochemical behaviors of 4-NP at the GO-film coated GCE were investigated in detail. In 0.1M acetate buffer with a pH of 4.8, 4-NP yields a very sensitive and well-defined reduction peak at the GO-modified GCE. It is found that the GO film exhibits obvious electrocatalytic activity toward the reduction of 4-NP since it not only increases the reduction peak current but also lowers the reduction overpotential. Based on this, an electrochemical method was proposed for the direct determination of 4-NP. Various kinetic parameters such as transfer electron number, transfer proton number and standard heterogeneous rate constant were calculated, and various experimental parameters were also optimized. Under the optimal conditions, the reduction peak current varies linearly with the concentration of 4-NP ranging from 0.1 to 120 μM, and the detection limit is 0.02 μM at the signal noise ratio of 3. Moreover, the fabricated sensor presented high selectivity and long-term stability. This electrochemical sensor was further applied to determine 4-NP in real water samples, and it showed great promise for simple, sensitive, and quantitative detection of 4-NP. Copyright © 2011 Elsevier B.V. All rights reserved.
                Bookmark

                Author and article information

                Journal
                J Anal Methods Chem
                J Anal Methods Chem
                JAMC
                Journal of Analytical Methods in Chemistry
                Hindawi Publishing Corporation
                2090-8865
                2090-8873
                2014
                12 May 2014
                : 2014
                : 424790
                Affiliations
                1School of Pharmacy, Lanzhou University, Lanzhou 730000, China
                2Gansu College of Traditional Chinese Medicine, Lanzhou 730000, China
                3Department of Chemistry, Lanzhou University, Lanzhou 730000, China
                Author notes

                Academic Editor: Jun-Jie Zhu

                Article
                10.1155/2014/424790
                4036735
                24900937
                bdb83c78-69a1-40fa-bd65-1314056f2233
                Copyright © 2014 Lin-jie Liu et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 5 March 2014
                : 14 April 2014
                Funding
                Funded by: National Science and Technology Support Program of China
                Award ID: 2011BAI05B02
                Categories
                Research Article

                Analytical chemistry
                Analytical chemistry

                Comments

                Comment on this article

                scite_

                Similar content184

                Cited by4

                Most referenced authors293