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      Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

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      Antiviral Research

      Elsevier BV

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          Abstract

          Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is available for use in humans. Here, we evaluated the efficacy of the pyrazinecarboxamide derivative T-705 (favipiravir) against Zaire Ebola virus (EBOV) in vitro and in vivo. T-705 suppressed replication of Zaire EBOV in cell culture by 4log units with an IC90 of 110μM. Mice lacking the type I interferon receptor (IFNAR(-)(/)(-)) were used as in vivo model for Zaire EBOV-induced disease. Initiation of T-705 administration at day 6 post infection induced rapid virus clearance, reduced biochemical parameters of disease severity, and prevented a lethal outcome in 100% of the animals. The findings suggest that T-705 is a candidate for treatment of Ebola hemorrhagic fever. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

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          Author and article information

          Journal
          Antiviral Research
          Antiviral Research
          Elsevier BV
          01663542
          May 2014
          May 2014
          : 105
          : 17-21
          Article
          10.1016/j.antiviral.2014.02.014
          24583123
          © 2014

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