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      Signal transduction cascades regulating fungal development and virulence.

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          Abstract

          Cellular differentiation, mating, and filamentous growth are regulated in many fungi by environmental and nutritional signals. For example, in response to nitrogen limitation, diploid cells of the yeast Saccharomyces cerevisiae undergo a dimorphic transition to filamentous growth referred to as pseudohyphal differentiation. Yeast filamentous growth is regulated, in part, by two conserved signal transduction cascades: a mitogen-activated protein kinase cascade and a G-protein regulated cyclic AMP signaling pathway. Related signaling cascades play an analogous role in regulating mating and virulence in the plant fungal pathogen Ustilago maydis and the human fungal pathogens Cryptococcus neoformans and Candida albicans. We review here studies on the signaling cascades that regulate development of these and other fungi. This analysis illustrates both how the model yeast S. cerevisiae can serve as a paradigm for signaling in other organisms and also how studies in other fungi provide insights into conserved signaling pathways that operate in many divergent organisms.

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          Author and article information

          Journal
          Microbiol Mol Biol Rev
          Microbiology and molecular biology reviews : MMBR
          American Society for Microbiology
          1092-2172
          1092-2172
          Dec 2000
          : 64
          : 4
          Affiliations
          [1 ] Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.
          Article
          10.1128/MMBR.64.4.746-785.2000
          99013
          11104818
          bdc75cb5-b922-43c2-8307-169da5500748
          History

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