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      Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers.

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          Abstract

          Brain metastases (BM) are common in non-small-cell lung cancer (NSCLC). However, the baseline incidence and evolution of BM over time in oncogene-driven NSCLCs are seldom reported. In this study, we evaluated the frequency of BM in patients with epidermal growth factor receptor (EGFR)-mutated or anaplastic lymphoma kinase (ALK)-rearranged NSCLC.

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          Author and article information

          Journal
          Lung Cancer
          Lung cancer (Amsterdam, Netherlands)
          Elsevier BV
          1872-8332
          0169-5002
          Apr 2015
          : 88
          : 1
          Affiliations
          [1 ] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
          [2 ] Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
          [3 ] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
          [4 ] Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
          [5 ] Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
          [6 ] Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Harvard Medical School, Boston, MA, United States.
          [7 ] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Electronic address: dbcosta@bidmc.harvard.edu.
          Article
          S0169-5002(15)00081-1 NIHMS661452
          10.1016/j.lungcan.2015.01.020
          4355240
          25682925
          bdd3316a-fbe7-426c-98c6-8caa5ec21b29
          History

          ALK,Brain metastases,CNS,Central nervous system,EGFR,Lung cancer,Mutation,NSCLC,Rearrangement

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