Effects of the ACE2 inhibitor GL1001 on acute dextran sodium sulfate-induced colitis in mice.

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Abstract

Angiotensin-converting enzyme 2 (ACE2) is expressed in gastrointestinal tissue. Previous studies of GL1001, a potent and selective ACE2 inhibitor, have revealed anti-inflammatory activity in the mouse digestive tract. We hypothesized that GL1001 might also produce beneficial effects in a mouse DSS model of inflammatory bowel disease.

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Journal

Journal ID (iso-abbrev): Inflamm Res

Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1420-908X

ISSN (Print): 1023-3830

Publication date (Electronic): Nov 2009

Volume: 58

Issue: 11

Affiliations

[1 ] Drug Repositioning and Selection, Ore Pharmaceuticals, Inc., Cambridge, MA 02139, USA. jbyrnes@orepharma.com

Article

DOI: 10.1007/s00011-009-0053-3

PubMed ID: 19517214

SO-VID: bdd99efc-279a-45bf-b95b-f99df80bf6c5

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