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      A history of exploring cancer in context

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      Nature Reviews Cancer
      Springer Nature

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          Abstract

          <p class="first" id="d6470938e69">The concept that progression of cancer is regulated by interactions of cancer cells with their microenvironment was postulated by Stephen Paget over a century ago. Contemporary tumour microenvironment (TME) research focuses on the identification of tumour-interacting microenvironmental constituents, such as resident or infiltrating non-tumour cells, soluble factors and extracellular matrix components, and the large variety of mechanisms by which these constituents regulate and shape the malignant phenotype of tumour cells. In this Timeline article, we review the developmental phases of the TME paradigm since its initial description. While illuminating controversies, we discuss the importance of interactions between various microenvironmental components and tumour cells and provide an overview and assessment of therapeutic opportunities and modalities by which the TME can be targeted. </p>

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          Author and article information

          Journal
          Nature Reviews Cancer
          Nat Rev Cancer
          Springer Nature
          1474-175X
          1474-1768
          April 26 2018
          Article
          10.1038/s41568-018-0006-7
          29700396
          bdf68c9e-6b6b-420b-b4ec-112fbdbb27b8
          © 2018

          http://www.springer.com/tdm

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