Immunoradiometric Assay of Active Renin versus Determination of Plasma Renin Activity in the Clinical Investigation of Hypertension, Congestive Heart Failure, and Liver Cirrhosis

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Abstract

We compared the determination of plasma renin activity (PRA) and the direct immunoradiometric measurement of active renin (AR) as ways of assessing the activity of the renin-angiotensin system in normal volunteers and in patients with hypertension, heart failure, or liver failure. The levels of plasma renin substrate, angiotensinogen, and the ratio of PRA to AR concentration did not differ in the normal volunteers and the patients with essential or renovascular hypertension. However, compared to the volunteers, patients with severe heart or liver failure had markedly reduced plasma renin substrate levels, which led to a considerable underestimation of AR concentration when it was measured by PRA.

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Journal ID (publisher-id): HRE

Journal ID (doi): 10.1159/issn.0018-5051

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-5316-2

ISBN: 978-3-318-01936-0

ISSN (Print): 0018-5051

ISSN (Electronic): 2571-6603

Publication date Subscription-year: 1990

Publication date (Print): 1990

Publication date (Electronic): 02 December 2008

Volume: 34

Issue: 3-4

Pages: 138-141

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Hôpital Broussais and Inserm U-36, Paris, France

Article

Publisher ID: 181813 Other ID: Horm Res 1990;34:138–141

DOI: 10.1159/000181813

SO-VID: be0a266b-9a2a-48aa-be37-084446256e73

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Immunoradiometric Assay of Active Renin versus Determination of Plasma Renin Activity in the Clinical Investigation of Hypertension, Congestive Heart Failure, and Liver Cirrhosis

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Karger: Endocrinology

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