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      Immunoradiometric Assay of Active Renin versus Determination of Plasma Renin Activity in the Clinical Investigation of Hypertension, Congestive Heart Failure, and Liver Cirrhosis

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          We compared the determination of plasma renin activity (PRA) and the direct immunoradiometric measurement of active renin (AR) as ways of assessing the activity of the renin-angiotensin system in normal volunteers and in patients with hypertension, heart failure, or liver failure. The levels of plasma renin substrate, angiotensinogen, and the ratio of PRA to AR concentration did not differ in the normal volunteers and the patients with essential or renovascular hypertension. However, compared to the volunteers, patients with severe heart or liver failure had markedly reduced plasma renin substrate levels, which led to a considerable underestimation of AR concentration when it was measured by PRA.

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          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 34
          : 3-4
          : 138-141
          Hôpital Broussais and Inserm U-36, Paris, France
          181813 Horm Res 1990;34:138–141
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 4
          Hormonal Control of Arterial Pressure and Water Electrolyte Metabolism


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