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      Research progress on genetic variants’ effects on childhood obesity interventions

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          Abstract

          In recent decades, the prevalence of childhood obesity has increased at a alarming rate. The health hazards of childhood obesity are substantial, which has become an important public health problem. Lifestyle intervention is an effective means to prevent childhood obesity. However, individuals varied in their response to the intervention program, which may be associated with genetic factors. This paper systematically reviews the research progress of the effects of FTO, MC4 R and other genetic variants on childhood obesity interventions, summarizes the limitations of current research and sheds light on the future research, so as to provide scientific evidence for individualized childhood obesity interventions based on genetic backgrounds.

          Abstract

          【摘要】 近几十年来, 儿童肥胖率持续上升, 健康危害严重, 巳成为重要公共卫生问题。生活方式干预是预防儿童肥胖的 有效手段。然而, 干预效果在不同个体间有一定差异, 可能由遗传因素导致。系统阐释 FTOMC4 R和其他基因变异对儿 童肥胖干预效果作用的研究进展, 总结目前研究的局限性及未来研究方向, 为制定基于遗传背景的儿童肥胖精准干预策略 提供依据。

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          Author and article information

          Journal
          CJSH
          Chinese Journal of School Health
          Chinese Journal of School Health (China )
          1000-9817
          01 November 2022
          01 November 2022
          : 43
          : 11
          : 1740-1744
          Affiliations
          [1] 1Department of Maternal and Child Health, School of Public Health, Peking University, Beijing (100191), China
          Author notes
          *Corresponding author: LIU Zheng, E-mail: liuzheng@ 123456bjmu.edu.cn
          Article
          j.cnki.1000-9817.2022.11.034
          10.16835/j.cnki.1000-9817.2022.11.034
          be189258-14c7-40db-9c6f-5ab973bc2787
          © 2022 Chinese Journal of School Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

          Product
          Self URI (journal-page): http://www.cjsh.org.cn
          Categories
          Journal Article

          Ophthalmology & Optometry,Pediatrics,Nutrition & Dietetics,Clinical Psychology & Psychiatry,Public health
          Genes,Intervention,Child,Obesity

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