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      The International Classification of Retinoblastoma predicts chemoreduction success.


      Antineoplastic Combined Chemotherapy Protocols, therapeutic use, Carboplatin, Child, Child, Preschool, Combined Modality Therapy, Cryotherapy, Etoposide, Humans, Hyperthermia, Induced, Infant, International Classification of Diseases, Reproducibility of Results, Retinal Neoplasms, classification, drug therapy, pathology, Retinoblastoma, Treatment Outcome, Vincristine

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          To evaluate the reliability of the International Classification of Retinoblastoma (ICRB) for predicting treatment success with chemoreduction (CRD). Noncomparative interventional case series. Two hundred forty-nine consecutive eyes. All eyes were treated with CRD and were classified according to the ICRB: group A included those eyes with retinoblastoma 3 mm, macular location, or minor subretinal fluid; group C included those eyes with retinoblastoma with localized seeds; group D included those eyes with retinoblastoma with diffuse seeds; group E included those eyes with massive retinoblastoma necessitating enucleation. The CRD regimen included vincristine, etoposide, and carboplatin for 6 cycles plus local consolidation with thermotherapy or cryotherapy. Chemoreduction success, defined as avoidance of external beam radiotherapy or enucleation. Of the 249 eyes, 23 (9%) were in group A, 96 (39%) were in group B, 21 (8%) were in group C, and 109 (44%) were in group D. In this series, group E eyes were managed with enucleation. Treatment success was achieved in 100% of group A, 93% of group B, 90% of group C, and 47% of group D eyes. The ICRB can be of assistance in predicting CRD success for retinoblastoma. Additional treatment methods are necessary to salvage more group D eyes.

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