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      Platelet-Rich Plasma: Support for Its Use in Wound Healing

      review-article
      , MMSc, PA-C, , MD, PhD *
      The Yale Journal of Biology and Medicine
      YJBM
      platelet-rich plasma, wounds, wound healing, autologous, therapy, diabetic foot, ulcer

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          Abstract

          Previous topical growth factor studies have shown that recombinant human platelet-derived growth factor-BB isomer (rhPDGF-BB) is an efficacious treatment of chronic diabetic foot ulceration. A newer treatment, autologous platelet-rich plasma (PRP), represents a greater similarity to the natural healing process as a composite of multiple growth factors, is safe due to its autologous nature, and is produced as needed from patient blood. A review of the literature shows few studies performed with scientific rigor, although the safety of PRP appears to be validated. As the use of PRP increases, additional studies may establish PRP as an efficacious treatment modality and guide future treatment of chronic diabetic foot ulceration.

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          Most cited references60

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          Platelet-rich plasma: evidence to support its use.

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            Platelet-rich plasma (PRP): what is PRP and what is not PRP?

            R Marx (2001)
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              Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings.

              Chronic wounds are a major healthcare problem costing the United States billions of dollars a year. The American Academy of Dermatology has underscored the significance of wound care in dermatological practice. It is critical for all dermatologists to understand the elements of diagnosis and therapy. We emphasize major aspects of diagnosis and present a simple classification of wound dressings with guidelines for usage and relative cost data. After completing this learning activity, participants should be able to diagnose common types of chronic wounds, formulate a therapeutic plan, and describe the major classes of topical therapies and dressings for the chronic wound.
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                Author and article information

                Journal
                Yale J Biol Med
                yjbm
                YJBM
                The Yale Journal of Biology and Medicine
                YJBM
                0044-0086
                1551-4056
                March 2010
                March 2010
                : 83
                : 1
                : 1-9
                Affiliations
                Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, and the VA Connecticut Healthcare System, West Haven, Connecticut
                Author notes
                [* ]To whom all correspondence should be addressed: Alan Dardik, MD, PhD, Yale University School of Medicine, Vascular Biology and Therapeutics, 10 Amistad Street, Room 437, PO Box 208089, New Haven, CT 06520-8089; Tele: 203-737-2213; Fax: 203-737-2290; E-mail: alan.dardik@ 123456yale.edu .
                Article
                2844688
                20351977
                be277849-845a-440b-b9a4-c6f35e907a23
                Copyright ©2010, Yale Journal of Biology and Medicine

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way.

                Categories
                Review

                Medicine
                wounds,ulcer,therapy,platelet-rich plasma,diabetic foot,wound healing,autologous
                Medicine
                wounds, ulcer, therapy, platelet-rich plasma, diabetic foot, wound healing, autologous

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