There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
An ab initio method for building structural models of proteins from x-ray solution
scattering data is presented. Simulated annealing is employed to find a chain-compatible
spatial distribution of dummy residues which fits the experimental scattering pattern
up to a resolution of 0.5 nm. The efficiency of the method is illustrated by the ab
initio reconstruction of models of several proteins, with known and unknown crystal
structure, from experimental scattering data. The new method substantially improves
the resolution and reliability of models derived from scattering data and makes solution
scattering a useful technique in large-scale structural characterization of proteins.