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      Distribution of Calcium in the Rat due to Chronic Renal Failure


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          During the 12 weeks following 5/6 nephrectomy in rats with moderate uremia (creatinine 0.7–1.2 mg/100 ml, BUN 53–89 mg/100 ml), no significant increases in total soft tissue calcification were observed. The calcium concentration of skeletal muscle remained unchanged at 4, 8, and 12 weeks after surgery. A slight but not significant increase in skin calcium was found. However, a significant decrease in cardiac calcium was found for the uremic animals. Total body calcium as determined by neutron activation analysis was significantly lower in the uremic rat when compared with the age-matched animal. However, when normalized for body weight, the total calcium content in uremic rats did not differ from the controls. Similar findings were observed for the absolute calcium content of the tibia and when normalized for weight. Furthermore, a highly significant linear relationship (r = 0.92, p < < 0.001) was established between absolute levels of total body calcium and tibia calcium which was identical for the control and uremic groups.

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          Author and article information

          S. Karger AG
          28 November 2008
          : 18
          : 2
          : 124-131
          Medical Research Center, Brookhaven National Laboratory, Upton, and Renal Unit, Nassau County Medical Center, East Meadow, New York, N. Y.
          180786 Nephron 1977;18:124–131
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 21 July 1975
          : 23 December 1975
          Page count
          Pages: 8
          Original Paper

          Cardiovascular Medicine,Nephrology
          Cardiac Ca,Neutron activation analysis,Muscle Ca,Metastatic calcification,Uremia,Skeletal Ca,Total body calcium,Skin Ca


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