Distribution of Calcium in the Rat due to Chronic Renal Failure

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Abstract

During the 12 weeks following 5/6 nephrectomy in rats with moderate uremia (creatinine 0.7–1.2 mg/100 ml, BUN 53–89 mg/100 ml), no significant increases in total soft tissue calcification were observed. The calcium concentration of skeletal muscle remained unchanged at 4, 8, and 12 weeks after surgery. A slight but not significant increase in skin calcium was found. However, a significant decrease in cardiac calcium was found for the uremic animals. Total body calcium as determined by neutron activation analysis was significantly lower in the uremic rat when compared with the age-matched animal. However, when normalized for body weight, the total calcium content in uremic rats did not differ from the controls. Similar findings were observed for the absolute calcium content of the tibia and when normalized for weight. Furthermore, a highly significant linear relationship (r = 0.92, p < < 0.001) was established between absolute levels of total body calcium and tibia calcium which was identical for the control and uremic groups.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1977

Publication date (Print): 1977

Publication date (Electronic): 28 November 2008

Volume: 18

Issue: 2

Pages: 124-131

Affiliations

Medical Research Center, Brookhaven National Laboratory, Upton, and Renal Unit, Nassau County Medical Center, East Meadow, New York, N. Y.

Article

Publisher ID: 180786 Other ID: Nephron 1977;18:124–131

DOI: 10.1159/000180786

PubMed ID: 854140

SO-VID: be3cd58c-f758-4109-b01b-42cd1627033b

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 21 July 1975

Date accepted : 23 December 1975

Page count

Pages: 8

Product

Self URI (application/pdf): https://www.karger.com/Article/Pdf/180786

Self URI (text/html): https://www.karger.com/Article/FullText/180786

Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology

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