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      Distribution of Calcium in the Rat due to Chronic Renal Failure

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          Abstract

          During the 12 weeks following 5/6 nephrectomy in rats with moderate uremia (creatinine 0.7–1.2 mg/100 ml, BUN 53–89 mg/100 ml), no significant increases in total soft tissue calcification were observed. The calcium concentration of skeletal muscle remained unchanged at 4, 8, and 12 weeks after surgery. A slight but not significant increase in skin calcium was found. However, a significant decrease in cardiac calcium was found for the uremic animals. Total body calcium as determined by neutron activation analysis was significantly lower in the uremic rat when compared with the age-matched animal. However, when normalized for body weight, the total calcium content in uremic rats did not differ from the controls. Similar findings were observed for the absolute calcium content of the tibia and when normalized for weight. Furthermore, a highly significant linear relationship (r = 0.92, p < < 0.001) was established between absolute levels of total body calcium and tibia calcium which was identical for the control and uremic groups.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1977
          1977
          28 November 2008
          : 18
          : 2
          : 124-131
          Affiliations
          Medical Research Center, Brookhaven National Laboratory, Upton, and Renal Unit, Nassau County Medical Center, East Meadow, New York, N. Y.
          Article
          180786 Nephron 1977;18:124–131
          10.1159/000180786
          854140
          © 1977 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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