For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
75
views
6
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      445
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Two Cases of Focal Scrotal Vitiligo Successfully Treated by Autologous Cultured Melanocyte Transplantation

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Vitiligo is an acquired cutaneous depigmentation disorder which has a deleterious effect on the psychosexual function of many individuals; the genitalia are the common site for depigmentation. Here, the authors report two cases of focal vitiligo affecting the scrotum of the genital organs which were successfully treated by autologous cultured melanocyte transplantation. Autologous cultured melanocyte transplantation on the scrotum is shown to be a relative effective method of treatment for vitiligo.

          Electronic supplementary material

          The online version of this article (doi:10.1007/s13555-014-0050-5) contains supplementary material, which is available to authorized users.

          Related collections

          Most cited references6

          • Record: found
          • Abstract: found
          • Article: not found

          Two therapeutic challenges: periocular and genital vitiligo in children successfully treated with pimecrolimus cream.

          Rubens Marcelo Souza Leite, Adriana Craveiro Leite (2007)
          Vitiligo is characterized by the selective destruction of melanocytes resulting in patches of skin depigmentation. Vitiligo is a therapeutic challenge. Eyebrows, eyelids and genital vitiligo are a therapeutic dilemma, especially in children. The possible side effects of topical corticosteroids and the difficulties for choosing any other adequate treatment option are a major concern. We present two children, one with vitiligo of the eyelids and the other with genital vitiligo, both treated with pimecrolimus 1% cream with almost full repigmentation of the lesions, showing pimecrolimus could be an adequate option for the treatment of vitiligo for these special vitiligo areas in children.
          Article 0 comments Cited 6 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Genital vitiligo treated by autologous, noncultured melanocyte-keratinocyte cell transplantation.

            Mohammed Eisa, Sanjeev Mulekar, Marwan Asaad … (2005)
            Genital vitiligo is common and has a deleterious effect on the psychosexual function of patients. It is well known that glabrous skin (non-hair-bearing skin such as below the ankles, genitalia, lips, distal ends of fingers) rarely responds to the therapy unless it has some residual pigment. The objective was to report genital vitiligo treated successfully by autologous, noncultured, melanocyte-keratinocyte cell transplantation. Three cases of clinically stable genital vitiligo were treated by autologous, noncultured melanocyte-keratinocyte cell transplantation. All lesions treated repigmented almost completely. All patients were very satisfied with the excellent cosmetic results. Autologous, noncultured melanocyte-keratinocyte cell transplantation may be an effective surgical treatment for management of genital vitiligo.
            Article 0 comments Cited 4 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Transplantation of melanocytes in vitiligo.

              L Juhlin, Tina M. Olsson (1995)
              We report the results of a study on 100 patients (aged 12-68) with vitiligo, who were treated by transplantation of cultured autologous melanocytes to the depigmented areas, after removal of the epidermis at the recipient site by dermabrasion. The melanocytes were cultured from a 2 x 3 cm2 superficial shave biopsy taken from pigmented buttock skin. After 2-3 weeks in culture, 700-1000 cells per mm2 were applied on 60-500 cm2 dermabraded areas, and occluded for 1 week. The repigmented portion of the total treated area amounted to 95-100% in 40 patients, 65-94% in 32, 20-64% in 22, and 0-19% in six. It was more difficult to achieve complete pigmentation on the fingers, elbows and knees. In the first few months following the procedure, the treated areas were often hypo- or hyperpigmented, but after 6-8 months they had acquired the same colour as the surrounding skin. No scarring or other side-effects occurred. The donor site had repigmented after 3-6 months in all but two patients, who also showed poor pigmentation in the transplanted areas. At follow-up after 1 and 2 years in 50 and 10 patients, respectively, the repigmented areas remained unchanged. The method is time-consuming, but the results obtained indicate that the procedure can be valuable in motivated patients, when the extent of vitiligo does not exceed 30% of the total body area, and when the areas to be treated are not actively extending.
              Article 0 comments Cited 4 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Xiaowen Li: 13293900584@163.com
                Ai-E Xu: xuaiehz@msn.com
                Journal
                Journal ID (nlm-ta): Dermatol Ther (Heidelb)
                Journal ID (iso-abbrev): Dermatol Ther (Heidelb)
                Title: Dermatology and Therapy
                Publisher: Springer Healthcare (Heidelberg )
                ISSN (Print): 2193-8210
                ISSN (Electronic): 2190-9172
                Publication date (Electronic): 27 March 2014
                Publication date PMC-release: 27 March 2014
                Publication date Collection: June 2014
                Volume: 4
                Issue: 1
                Pages: 141-144
                Affiliations
                Department of Dermatology, Third People’s Hospital of Hangzhou, The 2nd Affiliated Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China
                Article
                Publisher ID: 50
                DOI: 10.1007/s13555-014-0050-5
                PMC ID: 4065275
                PubMed ID: 24671856
                SO-VID: be4c8cf4-8a08-4b05-8f78-f568f510ef7a
                Copyright © © The Author(s) 2014
                History
                Date received : 10 February 2014
                Categories
                Subject: Case Report
                Custom metadata
                issue-copyright-statement © Springer Healthcare 2014

                ScienceOpen disciplines: Dermatology
                Keywords: autologous cultured melanocyte transplantation,dermatology,repigmentation,scrotal vitiligo
                Data availability:
                ScienceOpen disciplines: Dermatology
                Keywords: autologous cultured melanocyte transplantation, dermatology, repigmentation, scrotal vitiligo

                Comments

                Comment on this article