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      New octadecanoid derivatives from the seeds of Ipomoea nil

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          Abstract

          Four new octadecanoid derivatives ( 1- 4) including a pair of enantiomers ( 1/ 2), along with 12 known analogues ( 5- 16), were isolated from the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our bioassays revealed that these isolates did not show ABTS radical scavenging activity while 10 and 13 displayed better α-glucosidase inhibitory activity than the positive control acarbose (IC 50 167.7 ± 1.55 μmol-L −1), with IC 50 of 92.73 ± 3.12 and 11.39 ± 2.18 μmol-L −1, respectively.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 April 2019
          : 17
          : 4
          : 303-307
          Affiliations
          1 School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
          2 School of Biological Science and Technology, University of Jinan, Jinan 250022, China
          Author notes
          *Corresponding author: ZHANG Hua, Tel: 86-531-89736199, E-mail: bio_zhangh@ 123456ujn.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30034-2
          10.1016/S1875-5364(19)30034-2
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Natural Science Foundation of Shandong Province
          Award ID: JQ201721
          Funded by: Young Taishan Scholars Program
          Award ID: tsqn20161037
          Funded by: Director Foundation of XTIPC, CAS
          Award ID: 2015RC015
          Funded by: Shandong Talents Team Cultivation Plan of University Preponderant Discipline
          Award ID: 10027
          This work was supported by the Natural Science Foundation of Shandong Province (No. JQ201721), the Young Taishan Scholars Program (No. tsqn20161037), the Director Foundation of XTIPC, CAS (No. 2015RC015), and Shandong Talents Team Cultivation Plan of University Preponderant Discipline (No. 10027).

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