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      Studies of T Lymphocyte Function and Inhibitory Factors in Minimal Change Nephrotic Syndrome

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          Abstract

          Plasma obtained from patients with MCNS in active stage suppressed the <sup>3</sup>H-TdR incorporation of autologous or homologous lymphocytes stimulated with PHA-P and E rosette formation, while plasma from patients in remission did not. The depressed mitogenic response of lymphocytes from patients in the active stage significantly improved when the patient’s plasma was substituted for the plasma from inactive MCNS or healthy persons and fetal calf serum. In the preliminary experiment, it was seen that the inhibitory factors were heat stable at 56°C, unadsorbable to charcoal powder and retained in both the permeable and impermeable fractions of collodion bag.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1979
          1979
          02 December 2008
          : 24
          : 4
          : 179-182
          Affiliations
          Department of Pediatrics, Gunma University School of Medicine, Maebashi, Gunma
          Article
          181712 Nephron 1979;24:179–182
          10.1159/000181712
          315034
          © 1979 S. Karger AG, Basel

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          Pages: 4
          Categories
          Original Paper

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