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      Functionalized mesoporous silica materials for controlled drug delivery.

      1 , ,

      Chemical Society reviews

      Royal Society of Chemistry (RSC)

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          Abstract

          In the past decade, non-invasive and biocompatible mesoporous silica materials as efficient drug delivery systems have attracted special attention. Great progress in structure control and functionalization (magnetism and luminescence) design has been achieved for biotechnological and biomedical applications. This review highlights the most recent research progress on silica-based controlled drug delivery systems, including: (i) pure mesoporous silica sustained-release systems, (ii) magnetism and/or luminescence functionalized mesoporous silica systems which integrate targeting and tracking abilities of drug molecules, and (iii) stimuli-responsive controlled release systems which are able to respond to environmental changes, such as pH, redox potential, temperature, photoirradiation, and biomolecules. Although encouraging and potential developments have been achieved, design and mass production of novel multifunctional carriers, some practical biological application, such as biodistribution, the acute and chronic toxicities, long-term stability, circulation properties and targeting efficacy in vivo are still challenging.

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          Author and article information

          Journal
          Chem Soc Rev
          Chemical Society reviews
          Royal Society of Chemistry (RSC)
          1460-4744
          0306-0012
          May 07 2012
          : 41
          : 9
          Affiliations
          [1 ] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
          Article
          10.1039/c2cs15308d
          22441299

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