Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Gamma-Aminobutyric Acid-A Receptor-Mediated Suppression of 5-Hydroxytryptamine-Induced Guinea-Pig Basilar Artery Smooth Muscle Contractility

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The mechansim of γ -aminobutyric acid (GABA)-induced suppression of 5-hydroxytryptamine (5HT)-induced contractility of cerebral blood vessels was studied in single smooth muscle cells isolated from the guinea-pig basilar artery. GABA reduced 5HT-induced contraction of single smooth muscle cells, and the effect of GABA was mimicked by muscimol, but not baclofen. The response of muscimol was antagonized by bicuculline, thereby indicating that GABA<sub>A</sub> receptors exist on the smooth muscle of the basilar artery. Since GABA did not change the contraction induced by the addition of Ca<sup>2+</sup> to the Ca<sup>2+</sup>-free medium in the presence of high K<sup>+</sup>, it is unlikely that GABA inhibits the influx of extracellular Ca<sup>2+</sup>. The caffeine-induced contraction in the Ca<sup>2+</sup>-free medium was reduced by GABA, and the effect of GABA was not obtained by treatment with furosemide and in the Cl<sup>-</sup>-free medium. These results indicate that GABA acts on the GABA<sub>a</sub> receptor located on smooth muscle cells and reduces the contractility of the basilar artery by suppression of the mobilization of intracellular Ca<sup>2+</sup>.

          Related collections

          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1989
          1989
          23 September 2008
          : 26
          : 3
          : 129-136
          Affiliations
          Departments of aPharmacology and bNeurosurgery, Kobe University School of Medicine, Kobe, Japan
          Article
          158762 Blood Vessels 1989;26:129–136
          10.1159/000158762
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Research Paper

          Comments

          Comment on this article