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      A meta-analysis on the diagnostic utility of ultrasound in pediatric distal forearm fractures

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          Abstract

          Pediatric distal forearm fractures, comprising 30% of musculoskeletal injuries in children, are conventionally diagnosed using radiography. Ultrasound has emerged as a safer diagnostic tool, eliminating ionizing radiation, enabling bedside examinations with real-time imaging, and proving effective in non-hospital settings. The objective of this study is to evaluate the diagnostic efficacy of ultrasound for detecting distal forearm fractures in the pediatric population. A systematic review and meta-analysis were conducted through a comprehensive literature search in PubMed, Scopus, Web of Science, and Embase databases until October 1, 2023, following established guidelines. Eligible studies, reporting diagnostic accuracy measures of ultrasound in pediatric patients with distal forearm fractures, were included. Relevant data elements were extracted, and data analysis was performed. The analysis included 14 studies with 1377 patients, revealing pooled sensitivity and specificity of 94.5 (95% CI 92.7–95.9) and 93.5 (95% CI 89.6–96.0), respectively. Considering pre-test probabilities of 25%, 50%, and 75% for pediatric distal forearm fractures, positive post-test probabilities were 83%, 44%, and 98%, while negative post-test probabilities were 2%, 6%, and 15%, respectively. The bivariate model indicated significantly higher diagnostic accuracy in the subgroup with trained ultrasound performers vs. untrained performers ( p = 0.03). Furthermore, diagnostic accuracy was significantly higher in the subgroup examining radius fractures vs. ulna fractures ( p < 0.001), while no significant differences were observed between 4-view and 6-view ultrasound subgroups or between radiologist ultrasound interpreters and non-radiologist interpreters. This study highlighted ultrasound’s reliability in detecting pediatric distal forearm fractures, emphasizing the crucial role of expertise in precisely confirming fractures through ultrasound examinations.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s10140-024-02208-2.

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            QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies.

            In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
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              How to perform a meta-analysis with R: a practical tutorial

              Meta-analysis is of fundamental importance to obtain an unbiased assessment of the available evidence. In general, the use of meta-analysis has been increasing over the last three decades with mental health as a major research topic. It is then essential to well understand its methodology and interpret its results. In this publication, we describe how to perform a meta-analysis with the freely available statistical software environment R, using a working example taken from the field of mental health. R package meta is used to conduct standard meta-analysis. Sensitivity analyses for missing binary outcome data and potential selection bias are conducted with R package metasens. All essential R commands are provided and clearly described to conduct and report analyses. The working example considers a binary outcome: we show how to conduct a fixed effect and random effects meta-analysis and subgroup analysis, produce a forest and funnel plot and to test and adjust for funnel plot asymmetry. All these steps work similar for other outcome types. R represents a powerful and flexible tool to conduct meta-analyses. This publication gives a brief glimpse into the topic and provides directions to more advanced meta-analysis methods available in R.

                Author and article information

                Contributors
                Ali.Gholamrezanezhad@med.usc.edu
                Journal
                Emerg Radiol
                Emerg Radiol
                Emergency Radiology
                Springer International Publishing (Cham )
                1070-3004
                1438-1435
                5 February 2024
                5 February 2024
                2024
                : 31
                : 2
                : 213-228
                Affiliations
                [1 ]Department of Radiology, Keck School of Medicine, University of Southern California (USC), ( https://ror.org/03taz7m60) 1441 Eastlake Ave Ste 2315, Los Angeles, CA 90089 USA
                [2 ]Department of Radiology, Mayo Clinic, ( https://ror.org/02qp3tb03) Rochester, MN USA
                [3 ]School of Medicine, Tehran University of Medical Sciences, ( https://ror.org/01c4pz451) Tehran, Iran
                [4 ]School of Medicine, Shahid Beheshti University of Medical Sciences, ( https://ror.org/034m2b326) Tehran, Iran
                [5 ]GRID grid.67105.35, ISNI 0000 0001 2164 3847, Department of Radiology, , University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, ; Cleveland, OH USA
                [6 ]Department of Diagnostic and Interventional Imaging, McGovern Medical School, University of Texas Health Science Center at Houston, ( https://ror.org/03gds6c39) Houston, TX USA
                Author information
                http://orcid.org/0000-0001-6930-4246
                Article
                2208
                10.1007/s10140-024-02208-2
                10994871
                38311698
                be88e62f-0ade-4aa9-9c98-21d567c49099
                © The Author(s) 2024

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 23 December 2023
                : 24 January 2024
                Funding
                Funded by: University of Southern California
                Categories
                Review Article
                Custom metadata
                © American Society of Emergency Radiology 2024

                Emergency medicine & Trauma
                pediatrics,ultrasonography,forearm,radius fractures,ulna fractures
                Emergency medicine & Trauma
                pediatrics, ultrasonography, forearm, radius fractures, ulna fractures

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