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      Myocardial Metabolic Changes Related to Ventricular Fibrillation

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          Abstract

          The cause of death in patients who die suddenly or after an acute myocardial infarction is, in most cases, ventricular fibrillation. Most of these patients suffer from ischemic heart disease and atherosclerotic narrowing of the coronary arteries. Ischemic changes include hypoxia, accumulation of metabolites, depletion of energy-yielding substrates, ionic shifts and structural changes. There is an increased sympathetic activity and often a higher vagal tone. Recent observations support the idea that there is an elevated regional adrenergic activity in the ischemic area with increased tissue levels of cyclic AMP. This seems to be one of several important factors contributing to the occurrence of ventricular fibrillation. Increased sympathetic activity might mediate reentry mechanisms as well as enhanced automaticity.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1980
          1980
          31 October 2008
          : 65
          : 4
          : 226-247
          Affiliations
          Department of Medicine I, Sahlgren’s Hospital, University of Göteborg, Göteborg
          Article
          170817 Cardiology 1980;65:226–247
          10.1159/000170817
          6248218
          © 1980 S. Karger AG, Basel

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          Pages: 22
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