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      MicroRNA

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      Journal of Allergy and Clinical Immunology
      Elsevier BV

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          Abstract

          MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development. MiRNA mimics and miRNA inhibitors currently in preclinical development have shown promise as novel therapeutic agents. Multiple technological platforms have been developed for miRNA isolation, miRNA quantitation, miRNA profiling, miRNA target detection, and modulating miRNA levels in vitro and in vivo. Here we will review the major technological platforms with consideration given for the advantages and disadvantages of each platform.

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          Author and article information

          Journal
          Journal of Allergy and Clinical Immunology
          Journal of Allergy and Clinical Immunology
          Elsevier BV
          00916749
          April 2018
          April 2018
          : 141
          : 4
          : 1202-1207
          Article
          10.1016/j.jaci.2017.08.034
          5889965
          29074454
          beadf850-0be9-4b5e-b47f-6353ee33e2a9
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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