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      Co-administration of transient receptor potential vanilloid 4 (TRPV4) and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis.

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          Abstract

          To investigate transient receptor potential vanilloid 4 (TRPV4) expression in bladder afferents and study the effect of TRPV4 and TRPV1 antagonists, alone and in combination, in bladder hyperactivity and pain induced by cystitis.

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          Author and article information

          Journal
          BJU Int.
          BJU international
          1464-410X
          1464-4096
          Mar 2015
          : 115
          : 3
          Affiliations
          [1 ] Department of Renal, Urologic and Infectious Disease, Porto, Portugal; Department of Experimental Biology, Faculty of Medicine of the University of Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular da Universidade do Porto, Porto, Portugal.
          Article
          10.1111/bju.12861
          25041193
          © 2014 The Authors. BJU International © 2014 BJU International.

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