Blog
About

5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Indomethacin inhibits the accumulation of tumor cells in mouse lungs and subsequent growth of lung metastases.

      Chemotherapy

      Anti-Inflammatory Agents, Non-Steroidal, pharmacology, Carcinogenicity Tests, methods, Carcinoma, Lewis Lung, drug therapy, secondary, Cell Division, drug effects, Indomethacin, Lung Neoplasms, pharmacokinetics, pathology, Male, Mice, Mice, Inbred C57BL, Prostaglandin-Endoperoxide Synthases, Tissue Distribution, Uridine, Animals

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The interaction of cancer cells with blood cells and cell wall components evokes inflammatory responses and is a critical event in the metastatic process. Indomethacin is a potent inhibitor of the cyclooxygenase (COX) enzymes and has previously been shown to decrease the growth of primary tumors in vivo. Proinflammatory prostaglandins produced by the two COX enzymes may also play a role in the development of metastases. To directly address this question, we tested the effect of indomethacin on the accumulation of circulating [(3)H]-uridine-labeled tumor cells in the lungs and on the subsequent development of lung tumors. We found that inhibition of COX activity in the recipient mice prior to the injection of tumor cells decreased the percentage of the cells arrested in the lungs. This effect was highly significant since it subsequently led to substantial attenuation of lung metastasis development. These data thus demonstrate the antimetastatic effect of indomethacin through a mechanism which involves a reduction in tumor cell uptake by the lungs. Copyright 2000 S. Karger AG, Basel

          Related collections

          Author and article information

          Journal
          11053908
          7323

          Comments

          Comment on this article