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      Removal of perineuronal nets in the medial prefrontal cortex impairs the acquisition and reconsolidation of a cocaine-induced conditioned place preference memory.

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          Abstract

          Pyramidal neurons in the medial prefrontal cortex (mPFC) critically contribute to cocaine-seeking behavior in humans and rodents. Activity of these neurons is significantly modulated by GABAergic, parvalbumin-containing, fast-spiking interneurons, the majority of which are enveloped by specialized structures of extracellular matrix called perineuronal nets (PNNs), which are integral to the maintenance of many types of plasticity. Using a conditioned place preference (CPP) procedure, we found that removal of PNNs primarily from the prelimbic region of the mPFC of adult, male, Sprague Dawley rats impaired the acquisition and reconsolidation of a cocaine-induced CPP memory. This impairment was accompanied by a decrease in the number of c-Fos-positive cells surrounded by PNNs. Following removal of PNNs, the frequency of inhibitory currents in mPFC pyramidal neurons was decreased; but following cocaine-induced CPP, both frequency and amplitude of inhibitory currents were decreased. Our findings suggest that cocaine-induced plasticity is impaired by removal of prelimbic mPFC PNNs and that PNNs may be a therapeutic target for disruption of cocaine CPP memories.

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          Author and article information

          Journal
          J. Neurosci.
          The Journal of neuroscience : the official journal of the Society for Neuroscience
          1529-2401
          0270-6474
          Mar 11 2015
          : 35
          : 10
          Affiliations
          [1 ] Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, Washington 98686.
          [2 ] Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99164.
          [3 ] Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239.
          [4 ] Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, Departments of Neurology and Radiation Medicine, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon 97239, and.
          [5 ] School of Pharmacy and Department of Neuroscience, University of Wyoming, Laramie, Wyoming 82071.
          [6 ] Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, Washington 98686, sorg@vetmed.wsu.edu.
          Article
          35/10/4190
          10.1523/JNEUROSCI.3592-14.2015
          25762666
          bed6113f-d832-442f-88e2-e3e114ba70ac
          Copyright © 2015 the authors 0270-6474/15/354190-13$15.00/0.
          History

          cocaine,conditioned place preference,memory,perineuronal net

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