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      A Case of Multicentric Castleman’s Disease Associated with Renal Amyloidosis and Pure Red Cell Aplasia


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          This is the first reported case of multicentric Castleman’s disease (MCD) associated with renal amyloidosis and pure red cell aplasia (PRCA). Inguinal lymph node biopsy showed follicular hyperplasia with prominent germinal centers and plasma cell proliferation in the interfollicular areas. Renal biopsy specimens revealed intraglomerular amyloid deposits, defined as AA amyloidosis. Since amyloid deposits were not present in the gastric and rectal mucosal tissues, his renal disorder was found to be an unusual secondary amyloidosis associated with MCD. Following treatment by plasma exchange, there was progressive deterioration of anemia due to PRCA detected by bone marrow aspiration. Subsequently he was successfully treated with steroid pulse therapy not only for anemia but also for renal function.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          June 1998
          06 May 1998
          : 18
          : 3
          : 247-250
          Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
          13346 Am J Nephrol 1998;18:247–250
          © 1998 S. Karger AG, Basel

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          Page count
          Figures: 5, Tables: 1, References: 20, Pages: 4
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/13346
          Self URI (text/html): https://www.karger.com/Article/FullText/13346
          Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
          Case Report

          Cardiovascular Medicine,Nephrology
          Multicentric Castleman’s disease,Renal amyloidosis,Pure red cell aplasia,Steroid therapy


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