A Case of Multicentric Castleman’s Disease Associated with Renal Amyloidosis and Pure Red Cell Aplasia

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Abstract

This is the first reported case of multicentric Castleman’s disease (MCD) associated with renal amyloidosis and pure red cell aplasia (PRCA). Inguinal lymph node biopsy showed follicular hyperplasia with prominent germinal centers and plasma cell proliferation in the interfollicular areas. Renal biopsy specimens revealed intraglomerular amyloid deposits, defined as AA amyloidosis. Since amyloid deposits were not present in the gastric and rectal mucosal tissues, his renal disorder was found to be an unusual secondary amyloidosis associated with MCD. Following treatment by plasma exchange, there was progressive deterioration of anemia due to PRCA detected by bone marrow aspiration. Subsequently he was successfully treated with steroid pulse therapy not only for anemia but also for renal function.

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Journal ID (publisher-id): AJN

Journal ID (nlm-ta): Am J Nephrol

Journal ID (doi): 10.1159/issn.0250-8095

Title: American Journal of Nephrology

Publisher: S. Karger AG

ISSN (Print): 0250-8095

ISSN (Electronic): 1421-9670

Publication date Subscription-year: 1998

Publication date (Print): June 1998

Publication date (Electronic): 06 May 1998

Volume: 18

Issue: 3

Pages: 247-250

Affiliations

Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan

Article

Publisher ID: 13346 Other ID: Am J Nephrol 1998;18:247–250

DOI: 10.1159/000013346

PubMed ID: 9627044

SO-VID: bef41194-89b3-4129-ae8e-e4f0df60c15b

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A Case of Multicentric Castleman’s Disease Associated with Renal Amyloidosis and Pure Red Cell Aplasia

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Karger: Nephrology

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