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      Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'.

      1 ,
      Nature protocols
      Springer Science and Business Media LLC

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          Abstract

          Rats and mice have a tendency to interact more with a novel object than with a familiar object. This tendency has been used by behavioral pharmacologists and neuroscientists to study learning and memory. A popular protocol for such research is the object-recognition task. Animals are first placed in an apparatus and allowed to explore an object. After a prescribed interval, the animal is returned to the apparatus, which now contains the familiar object and a novel object. Object recognition is distinguished by more time spent interacting with the novel object. Although the exact processes that underlie this 'recognition memory' requires further elucidation, this method has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.

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          Author and article information

          Journal
          Nat Protoc
          Nature protocols
          Springer Science and Business Media LLC
          1750-2799
          1750-2799
          2006
          : 1
          : 3
          Affiliations
          [1 ] Department of Psychology, 238 Burnett Hall, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, USA. rbevins1@unl.edu
          Article
          nprot.2006.205
          10.1038/nprot.2006.205
          17406415
          bef7c858-fcb4-4851-95cf-88ef12afffdf
          History

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