[1
]Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics,
Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University,
Cardiff, UK.
[2
]Inserm U744, F-59019 Lille, France.
[3
]Institut Pasteur de Lille, F-59019, Lille, France.
[4
]Université de Lille Nord de France, F-59000 Lille, France.
[5
]Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida,
USA.
[6
]National Institute for Health Research Biomedical Research Centre for Mental Health
at the South London and Maudsley National Health Service Foundation Trust and Institute
of Psychiatry, Kings College, London, UK.
[7
]Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK.
[8
]Institute of Public Health, University of Cambridge, Cambridge, UK.
[9
]Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
[10
]Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College,
Dublin, Ireland.
[11
]Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham,
UK.
[12
]Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical
Sciences, Queen’s University Belfast, UK.
[13
]Division of Clinical Neurosciences, School of Medicine, University of Southampton,
Southampton, UK.
[14
]Neurodegeneration and Mental Health Research Group, School of Community Based Medicine,
University of Manchester, Hope Hospital, Stott Lane, Salford, Manchester, UK.
[15
]Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, John
Radcliffe Hospital, Oxford, UK.
[16
]Nuffield Department of Clinical Medicine, Medical Sciences Division. University of
Oxford, Headington, Oxford. OX3 7BN. UK.
[17
]Dementia Research Group, University of Bristol Institute of Clinical Neurosciences,
Frenchay Hospital, Bristol, UK.
[18
]Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, LIGHT
Laboratories, University of Leeds, LS2 9JT, UK
[19
]Cerebral Function Unit, Salford Royal NHS Trust, Stott Lane, Salford, M6 8HD, UK.
[20
]Department of Molecular Neuroscience, Institute of Neurology, London, UK.
[21
]Reta Lilla Weston Laboratories, Institute of Neurology, London, UK.
[22
]Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
[23
]Department of Psychiatry, University of Bonn, Bonn, Germany.
[24
]German Centre for Neurodegenerative Diseases, Bonn, Bonn, Germany.
[25
]Institute for Molecular Psychiatry, University of Bonn, Bonn, Germany.
[26
]Department of Psychiatry, University of Göttingen, Germany.
[27
]Department of Psychiatry, Royal Derby Hospital, Derby, DE22 3WQ, UK.
[28
]Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Germany.
[29
]Department of Psychiatry, Charité Berlin, Berlin, Germany.
[30
]Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Germany.
[31
]Landschaftsverband Rheinland-Hospital Essen, Department of Psychiatry and Psychotherapy,
University Duisburg-Essen, Essen, Germany.
[32
]Department of Neurology, Klinikum der Universität München, Munich, Germany.
[33
]Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich,
Germany.
[34
]Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty
Mannheim, University of Heidelberg, Mannheim, Germany.
[35
]Department of Psychiatry, Psychsomatic Medicine and Psychotherapy, Johann Wolfgang
Goethe-University, Frankfurt, Germany.
[36
]Department of Primary Care and Public Health, School of Medicine, Cardiff University,
Cardiff, UK.
[37
]Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri,
USA.
[38
]Department of Neurology, Washington University School of Medicine, St Louis, Missouri,
USA.
[39
]Department of Genetics, Washington University School of Medicine, St Louis, Missouri,
USA.
[40
]Department of Biology, Brigham Young University, Provo, Utah, USA.
[41
]Institute Born-Bunge and University of Antwerp, Antwerpen, Belgium.
[42
]Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerpen,
Belgium.
[43
]Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium.
[44
]Department of Mental Health Sciences, University College London, UK.
[45
]The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge,
UK.
[46
]MRC Centre for Neurodegeneration Research, Department of Clinical Neuroscience, King’s
College London, Institute of Psychiatry, London, UK.
[47
]Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki,
Greece.
[48
]Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health,
Bethesda, Maryland, USA.
[49
]Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
[50
]Institute of Human Genetics, University of Bonn, Bonn, Germany.
[51
]Institute for Medical Informatics, Biometry and Epidemiology, University Hospital
of Essen, University Duisburg-Essen, Essen, Germany.
[52
]Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental
Health, Neuherberg, Germany.
[53
]Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität,
Munich, Germany.
[54
]Klinikum Grosshadern, Munich, Germany.
[55
]Division of Biomedical Statistics and Informatics, Mayo Clinic and Mayo Foundation,
Rochester, Minnesota, USA.
[56
]Department of Neurology, St. Olav’s Hospital, Edvard Griegs Gate 8, 7006 Trondheim,
Norway.
[57
]Department of Neuroscience, Norwegian University of Science and Technology, NTNU,
7491 Trondheim, Norway.
[58
]Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy
of Sciences, Warsaw, Poland.
[59
]Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL 32224,
USA.
[60
]Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
[61
]Mayo Alzheimer Disease Research Center, Mayo Clinic College of Medicine, Rochester,
MN 55905, USA.
[62
]Data used in the preparation of this article were obtained from the Alzheimer’s Disease
Neuroimaging Initiative (ADNI) database (
www.loni.ucla.edu\ADNI). As such, the investigators within the ADNI contributed to the design and implementation
of ADNI and/or provided data but did not participate in analysis or writing of this
report. ADNI investigators include (complete listing available at
www.loni.ucla.edu\ADNI\Collaboration\ADNI_Authorship_list.pdf).
[63
]Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
[64
]Netherlands Consortium for Healthy Aging, The Netherlands.
[65
]Departments of Neurology and Biostatistics, Boston University School of Medicine,
Boston, Massachussets, USA.
[66
]The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham,
Massachussets, USA.
[67
]Department of Epidemiology, University of Washington, Seattle, Washington, USA.
[68
]Department of Neurology, The Alzheimer’s Disease Research Center, University of Pittsburgh
School of Medicine, Pittsburgh, Pennsylvania, USA.
[69
]Department of Psychiatry, The Alzheimer’s Disease Research Center, University of Pittsburgh
School of Medicine, Pittsburgh, Pennsylvania, USA.
[70
]Neuroepidemiology Section, Laboratory of Epidemiology, Demography and Biometry (LJL),
National Institute on Aging, Washington DC, USA.
[71
]Department of Neurology, Boston University School of Medicine, Boston, Massachussets,
USA.
[72
]Inserm U888, Hôpital La Colombière, Montpellier, France.
[73
]Inserm U614, Faculté de Médecine-Pharmacie de Rouen, Rouen, France.
[74
]UMR 894, Inserm Faculté de Médecine, Université Paris Descartes, Paris, France.
[75
]Inserm U897, Victor Segalen University, Bordeaux, France.
[76
]Inserm U708, Paris, France.
[77
]Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique,
Evry, France.
[78
]Fondation Jean Dausset- CEPH, Paris, France.
[79
]Department of Psychiatry and Psychotherapy, Universitätsklinikum des Saarlandes, Universität
des Saarlandes, Germany.
[80
]Institute of Medical Informatics and Statistics, Christian-Albrechts-University, Kiel,
Germany.
[81
]Biobank Popgen, Institute of Experimental Medicine, Section of Epidemiology, Christian-Albrechts
University, Kiel, Germany
[82
]Institute for Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
[83
]Inst. of Medical Statistics and Epidemiology; Klinikum Rechts der Isar, TU-München,
Germany.
[84
]deCODE Genetics, Reykjavik, Iceland.
[85
]deCODE Genetics and University of Iceland, Faculty of Medicine, Reykjavik, Iceland.
[86
]Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[87
]Department of Neurology, University of Eastern Finland and Kuopio University Hospital,
70211, Kuopio, Finland.
[88
]Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria),
Santander, Spain.
[89
]CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander,
Spain.
[90
]Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique,
Evry, France.
[91
]Centro de Biologia Molecular Severo Ochoa (CSIC-UAM, Universidad Autonoma, Campus
de Cantoblanco, S-28049, Madrid, Spain.
[92
]Centre Hospitalier Régional Universitaire de Lille, Lille, France.
[93
]Servicio de Neurologia, Hospital Universitario La Paz (UAM) 28034 Madrid, Spain.
[94
]Department of Experimental Pathology, School of Medicine, University of Bologna, Italy.
[95
]Departement de Geriatrie, CHU de Dijon, F-21000, Dijon, France.
[96
]Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo,
Spain.
[97
]IRCCS Oasi Maria SS, 94018 Troina , Italy
[98
]Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy.
[99
]Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari,
Policlinico, 70124 Bari , Italy.
[100
]Department of Neurological and Psychiatric Sciences, University of Florence, 50134
Florence, Italy.
[101
]Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179
Roma, Italy.
[102
]Lab of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience,
University of Cagliari, Italy.
[103
]Department of Internal Medicine, Università degli Studi di Milano, Fondazione IRCCS,
Ospedale Maggiore, Mangiagalli e Regina Elena, Milan Italy.
[104
]Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza
Italy.
[105
]Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical
Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy.
[106
]Dept. of Neurological Sciences, University of Milan, 35 via F. Sforza, Milan, 20122,
Italy.
[107
]Inserm, UMR_S679, Hopital de la salpétirère, 75651 Paris, France.
[108
]Inserm U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France.
