For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
23
views
43
references
 Top references
cited by
71
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      193
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The molecular mechanism of intervertebral disc degeneration (IVDD) remains unclear. This study aimed to investigate the role of circular RNAs (circRNAs) in the pathogenesis of IVDD. We sued nucleus pulposus (NP) tissues of patients, tert-butyl hydroperoxide (TBHP) stimulated NP cells (NPCs), and IVDD rat model to explore the interaction between circERCC2 and miR-182-5p/SIRT1 axis. The results showed that downregulation of circERCC2 increased the level of miR-182-5p and decreased the level of SIRT1 in degenerative NP tissues in vivo as well as in TBHP-stimulated NPCs in vitro. Treatment of SIRT1-si activated apoptosis and inhibited mitophagy. Moreover, miR-182-5p-si could regulate the mitophagy and the apoptosis of NPCs by targeting SIRT1. The effects of circERCC2 on NPCs and IVDD rat model were mediated by miR-182-5p/SIRT1 axis. In conclusion, this study provides the first evidence that circERCC2 could ameliorate IVDD through miR-182-5p/SIRT1 axis by activating mitophagy and inhibiting apoptosis, and suggests that circERCC2 is a potentially effective therapeutic target for IVDD.

          Related collections

          Most cited references43

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          miRWalk: An online resource for prediction of microRNA binding sites

          Carsten Sticht, Carolina de la Torre, Alisha Parveen … (2018)
          miRWalk is an open-source platform providing an intuitive interface that generates predicted and validated miRNA-binding sites of known genes of human, mouse, rat, dog and cow. The core of miRWalk is the miRNA target site prediction with the random-forest-based approach software TarPmiR searching the complete transcript sequence including the 5’-UTR, CDS and 3’-UTR. Moreover, it integrates results other databases with predicted and validated miRNA-target interactions. The focus is set on a modular design and extensibility as well as a fast update cycle. The database is available using Python, MySQL and HTML/Javascript Database URL: http://mirwalk.umm.uni-heidelberg.de.
          Article 0 comments Cited 629 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Low back pain in relation to lumbar disc degeneration.

            Katariina Luoma, Hilkka Riihimäki, Ritva Luukkonen … (2000)
            Cross-sectional magnetic resonance imaging (MRI) study. To study the relation of low back pain (LBP) to disc degeneration in the lumbar spine. Controversy still prevails about the relationship between disc degeneration and LBP. Classification of disc degeneration and symptoms varies, hampering comparison of study results. Subjects comprised 164 men aged 40-45 years-53 machine drivers, 51 construction carpenters, and 60 office workers. The data of different types of LBP, individual characteristics, and lifestyle factors were obtained from a questionnaire and a structured interview. Degeneration of discs L2/L3-L5/S1 (dark nucleus pulposus and posterior and anterior bulge) was assessed with MRI. An increased risk of LBP (including all types) was found in relation to all signs of disc degeneration. An increased risk of sciatic pain was found in relation to posterior bulges, but local LBP was not related to disc degeneration. The risks of LBP and sciatic pain were strongly affected by occupation. Low back pain is associated with signs of disc degeneration and sciatic pain with posterior disc bulges. Low back pain is strongly associated with occupation.
            Article 0 comments Cited 328 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data

              Weijun Liu, Xiaowei Wang (2019)
              We perform a large-scale RNA sequencing study to experimentally identify genes that are downregulated by 25 miRNAs. This RNA-seq dataset is combined with public miRNA target binding data to systematically identify miRNA targeting features that are characteristic of both miRNA binding and target downregulation. By integrating these common features in a machine learning framework, we develop and validate an improved computational model for genome-wide miRNA target prediction. All prediction data can be accessed at miRDB (http://mirdb.org). Electronic supplementary material The online version of this article (10.1186/s13059-019-1629-z) contains supplementary material, which is available to authorized users.
              Article 0 comments Cited 305 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Hongli Wang: shrrng0@gmail.com
                Jianyuan Jiang: 18111220066@fudan.edu.cn
                Journal
                Journal ID (nlm-ta): Cell Death Dis
                Journal ID (iso-abbrev): Cell Death Dis
                Title: Cell Death & Disease
                Publisher: Nature Publishing Group UK (London )
                ISSN (Electronic): 2041-4889
                Publication date (Electronic): 3 October 2019
                Publication date PMC-release: 3 October 2019
                Publication date Collection: October 2019
                Volume: 10
                Issue: 10
                Electronic Location Identifier: 751
                Affiliations
                [1 ]ISNI 0000 0001 0125 2443, GRID grid.8547.e, Department of Orthopedics, Huashan Hospital, , Fudan University, ; 12 Mid-Wulumuqi Road, Shanghai, 200040 China
                [2 ]ISNI 0000 0004 0368 7223, GRID grid.33199.31, Department of Orthopedic Surgery, Wuhan Fourth Hospital, , Huazhong University of Science and Technology, ; 473 Hanzheng Street, Wuhan, 430000 China
                [3 ]ISNI 0000 0000 9868 173X, GRID grid.412787.f, Department of Spinal Surgery, Wuhan Puren Hospital, , Wuhan University of Science and Technology, ; 1 Benxi Street, Wuhan, 430080 China
                [4 ]ISNI 0000 0001 2323 5732, GRID grid.39436.3b, Laboratory of Neuropharmacology and Neurotoxicology, , Shanghai University, ; 381 Nanchen Road, Shanghai, 200436 China
                [5 ]ISNI 0000 0001 0125 2443, GRID grid.8547.e, Department of Orthopedic Surgery, Jinshan Hospital, , Fudan University, ; 1508 Longhang Road, Shanghai, 201508 China
                [6 ]ISNI 0000 0001 0125 2443, GRID grid.8547.e, Department of Orthopedic Surgery, The Fifth People’s Hospital of Shanghai, , Fudan University, ; 128 Ruili Road, Shanghai, 201100 China
                Article
                Publisher ID: 1978
                DOI: 10.1038/s41419-019-1978-2
                PMC ID: 6776655
                PubMed ID: 31582722
                SO-VID: befd6b23-2c41-40cd-9822-cbd104165c7a
                Copyright © © The Author(s) 2019
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 17 July 2019
                Date revision received : 4 September 2019
                Date accepted : 16 September 2019
                Funding
                Funded by: FundRef https://doi.org/10.13039/501100001809, National Natural Science Foundation of China (National Science Foundation of China);
                Award ID: 81802145
                Award ID: 81772388
                Award ID: 81772388
                Award ID: 81802145
                Award ID: 81802145
                Award ID: 81772388
                Award Recipient :
                Categories
                Subject: Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2019

                ScienceOpen disciplines: Cell biology
                Keywords: mitophagy,mirnas,rnai
                Data availability:
                ScienceOpen disciplines: Cell biology
                Keywords: mitophagy, mirnas, rnai

                Comments

                Comment on this article

                scite_

                Similar content193

                See all similar

                Cited by71

                See all cited by

                Most referenced authors887

                See all reference authors