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      Frail-VIG index: a concise frailty evaluation tool for rapid geriatric assessment

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          Abstract

          Background

          Demographic changes have led to an increase in the number of elderly frail persons and, consequently, systematic geriatric assessment is more important than ever. Frailty Indexes (FI) may be particularly useful to discriminate between various degrees of frailty but are not routinely assessed due, at least in part, to the large number of deficits assessed (from 30 to 70). Therefore, we have developed a new, more concise FI for rapid geriatric assessment (RGA)—the Frail-VIG index (“VIG” is the Spanish/Catalan abbreviation for Comprehensive Geriatric Assessment), which contains 22 simple questions that assess 25 different deficits. Here we describe this FI and report its ability to predict mortality at 24 months.

          Methods

          Prospective, observational, longitudinal study of geriatric patients followed for 24 months or until death. The study participants were patients ( n = 590) admitted to the Acute Geriatric Unit at the at the University Hospital of Vic (Barcelona) during the year 2014. Participants were classified into one of seven groups based on their Frail-VIG score (0–0.15; 0.16–0.25; 0.26–0.35; 0.36–0.45; 0.46–0.55; 0.56–0.65; and 0.66–1). Survival curves for these groups were compared using the log-rank test. ROC curves were used to assess the index’s capacity to predict mortality at 24 months.

          Results

          Mean (standard deviation) patient age was 86.4 (5.6) years. The 24-month mortality rate was 57.3% for the whole sample. Significant between-group (deceased vs. living) differences ( p < 0.05) were observed for most index variables. Survival curves for the seven Frail-VIG groups differed significantly (X 2 = 433.4, p < 0.001), with an area under the ROC curve (confidence interval) of 0.90 (0.88–0.92) at 12 months and 0.85 (0.82–0.88) at 24 months. Administration time for the Frail-VIG index ranged from 5 to 10 min.

          Conclusions

          The Frail-VIG index, which requires less time to administer than previously validated FIs, presents a good discriminative capacity for the degree of frailty and a high predictive capacity for mortality in the present cohort. Although more research is needed to confirm the validity of this instrument in other populations and settings, the Frail-VIG may provide clinicians with a RGA method and also a reliable tool to assess frailty in routine practice.

          Electronic supplementary material

          The online version of this article (10.1186/s12877-018-0718-2) contains supplementary material, which is available to authorized users.

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          Most cited references31

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          Frailty defined by deficit accumulation and geriatric medicine defined by frailty.

          As nonreplicative cells age, they commonly accumulate subcellular deficits that can compromise function. As people age, they too experience problems that can accumulate. As deficits (symptoms, signs, illnesses, disabilities) accumulate, people become more susceptible to adverse health outcomes, including worse health and even death. This state of increased risk of adverse health outcomes is indistinguishable from the idea of frailty, so deficit accumulation represents another way to define frailty. Counting deficits not only allows grades of frailty to be discerned but also provides insights into the complex problems of older adults. This process is potentially useful to geriatricians who need to be experts in managing complexity. A key to managing complexity is through instruments such as a comprehensive geriatric assessment, which can serve as the basis for routine clinical estimation of an individual's degree of frailty. Understanding people and their needs as deficits accumulate is an exciting challenge for clinical research on frailty and its management by geriatricians. Copyright © 2011 Elsevier Inc. All rights reserved.
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            Frailty: An Emerging Public Health Priority.

            The absolute and relative increases in the number of older persons are evident worldwide, from the most developed countries to the lowest-income regions. Multimorbidity and need for social support increase with age. Age-related conditions and, in particular, disabilities are a significant burden for the person, his or her family, and public health care systems. To guarantee the sustainability of public health systems and improve the quality of care provided, it is becoming urgent to act to prevent and delay the disabling cascade. Current evidence shows that too large a proportion of community-dwelling older people present risk factors for major health-related events and unmet clinical needs. In this scenario, the "frailty syndrome" is a condition of special interest. Frailty is a status of extreme vulnerability to endogenous and exogenous stressors exposing the individual to a higher risk of negative health-related outcomes. Frailty may represent a transition phase between successful aging and disability, and a condition to target for restoring robustness in the individual at risk. Given its syndromic nature, targeting frailty requires a comprehensive approach. The identification of frailty as a target for implementing preventive interventions against age-related conditions is pivotal. Every effort should be made by health care authorities to maximize efforts in this field, balancing priorities, needs, and resources. Raising awareness about frailty and age-related conditions in the population is important for effective prevention, and should lead to the promotion of lifelong healthy behaviors and lifestyle.
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              The frailty phenotype and the frailty index: different instruments for different purposes.

              The integration of frailty measures in clinical practice is crucial for the development of interventions against disabling conditions in older persons. The frailty phenotype (proposed and validated by Fried and colleagues in the Cardiovascular Health Study) and the Frailty Index (proposed and validated by Rockwood and colleagues in the Canadian Study of Health and Aging) represent the most known operational definitions of frailty in older persons. Unfortunately, they are often wrongly considered as alternatives and/or substitutables. These two instruments are indeed very different and should rather be considered as complementary. In the present paper, we discuss about the designs and rationals of the two instruments, proposing the correct ways for having them implemented in the clinical setting.
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                Author and article information

                Contributors
                +34 628190415 , jordiamblas@gmail.com
                martori@uvic.cat
                jespaulella@hsc.chv.cat
                ramon.oller@uvic.cat
                nmolist@gmail.com
                minzitari@perevirgili.cat
                roman.romero-ortuno@nhs.net
                Journal
                BMC Geriatr
                BMC Geriatr
                BMC Geriatrics
                BioMed Central (London )
                1471-2318
                26 January 2018
                26 January 2018
                2018
                : 18
                : 29
                Affiliations
                [1 ]GRID grid.476405.4, Geriatric and Palliative Care Department, , Hospital Universitari de la Santa Creu / Hospital Universitari de Vic, ; Rambla Hospital 52, 08500 Vic, Barcelona Spain
                [2 ]GRID grid.440820.a, Department of Palliative Care, , University of Vic / Central University of Catalonia, ; Barcelona, Spain
                [3 ]ISNI 0000000123317762, GRID grid.454735.4, Programme for the Prevention and Care of Patients with Chronic Conditions, Department of Health, Government of Catalonia, ; Barcelona, Spain
                [4 ]GRID grid.440820.a, Data Analysis and Modeling Research Group. Department of Economics and Business, , University of Vic / Central University of Catalonia, ; Barcelona, Spain
                [5 ]GRID grid.7080.f, Parc Sanitari Pere Virgili. Universitat Autònoma de Barcelona, ; Barcelona, Spain
                [6 ]ISNI 0000 0004 0622 5016, GRID grid.120073.7, Department of Medicine for the Elderly, , Addenbrooke’s Hospital, ; Cambridge, UK
                [7 ]ISNI 0000000121885934, GRID grid.5335.0, Department of Public Health and Primary Care, Clinical Gerontology Unit, , University of Cambridge, ; Cambridge, UK
                Author information
                http://orcid.org/0000-0002-2338-3054
                Article
                718
                10.1186/s12877-018-0718-2
                5787254
                29373968
                bf282d86-2b10-4293-ac1a-a593a6b14a2d
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 10 October 2017
                : 14 January 2018
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2018

                Geriatric medicine
                frail elderly,frailty index,geriatric assessment,multimorbidity,mortality
                Geriatric medicine
                frail elderly, frailty index, geriatric assessment, multimorbidity, mortality

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