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      Role of Growth Hormone in Glucose Counterregulation

      Hormone Research in Paediatrics

      S. Karger AG

      Hypoglycemia, Cortisol, Glucagon, Epinephrine, Growth hormone

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          Glucose counterregulation, the physiological mechanisms that normally very effectively prevent or correct hypoglycemia, involves both dissipation of insulin and activation of glucose counterregulatory (glucose-raising) systems. Glucagon and epinephrine stand high in the hierarchy of redundant counterregulatory factors. Hypoglycemia develops or progresses when both glucagon and epinephrine are deficient and insulin is present despite the actions of other glucose-counterregulatory factors. Growth hormone (like cortisol) is demonstrably involved in defense against prolonged (as opposed to short-term) hypoglycemia, but it is not critical to recovery from even prolonged hypoglycemia or to the prevention of hypoglycemia after an overnight fast. Thus, growth hormone, like cortisol, stands lower in the hierarchy of the redundant glucose-counterregulatory factors.

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          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          09 December 2008
          : 46
          : 4-5
          : 192-194
          Division of Endocrinology, Diabetes and Metabolism of the Department of Medicine, and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St. Louis, Mo., USA
          185022 Horm Res 1996;46:192–194
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 3
          Session 2: GH, IGF-I and Metabolism


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