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      Transient elastography: a new noninvasive method for assessment of hepatic fibrosis

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          Abstract

          Chronic hepatitis is accompanied by progressive deposit of hepatic fibrosis, which may lead to cirrhosis. Evaluation of liver fibrosis is, thus, of great clinical interest and, up to now, has been assessed with liver biopsy. This work aims to evaluate a new noninvasive device to quantify liver fibrosis: the shear elasticity probe or fibroscan. This device is based on one-dimensional (1-D) transient elastography, a technique that uses both ultrasound (US) (5 MHz) and low-frequency (50 Hz) elastic waves, whose propagation velocity is directly related to elasticity. The intra- and interoperator reproducibility of the technique, as well as its ability to quantify liver fibrosis, were evaluated in 106 patients with chronic hepatitis C. Liver elasticity measurements were reproducible (standardized coefficient of variation: 3%), operator-independent and well correlated (partial correlation coefficient = 0.71, p < < 0.0001) to fibrosis grade (METAVIR). The areas under the receiver operating characteristic (ROC) curves were 0.88 and 0.99 for the diagnosis of patients with significant fibrosis (>/= F2) and with cirrhosis ( = F4), respectively. The Fibroscan is a noninvasive, painless, rapid and objective method to quantify liver fibrosis.

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          Author and article information

          Journal
          Ultrasound in Medicine & Biology
          Ultrasound in Medicine & Biology
          Elsevier BV
          03015629
          December 2003
          December 2003
          : 29
          : 12
          : 1705-1713
          Article
          10.1016/j.ultrasmedbio.2003.07.001
          14698338
          bf37f09f-7223-4e99-a6b8-21ac4b08fd99
          © 2003

          https://www.elsevier.com/tdm/userlicense/1.0/

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