Visual Systems and the Role of Vision in Subterranean Rodents: Diversity of Retinal Properties and Visual System Designs

Our eyes send different 'images' of the outside world to the brain - an image of contours (line drawing), a colour image (watercolour painting) or an image of moving objects (movie). This is commonly referred to as parallel processing, and starts as early as the first synapse of the retina, the cone pedicle. Here, the molecular composition of the transmitter receptors of the postsynaptic neurons defines which images are transferred to the inner retina. Within the second synaptic layer - the inner plexiform layer - circuits that involve complex inhibitory and excitatory interactions represent filters that select 'what the eye tells the brain'.

All mammalian retinae contain rod photoreceptors for low-light vision and cone photoreceptors for daylight and color vision. Most nonprimate mammals have dichromatic color vision based on two cone types with spectrally different visual pigments: a short-wavelength-sensitive (S-)cone and a long-wavelength-sensitive (L-)cone. Superimposed on this basic similarity, there are remarkable differences between species. This article reviews some striking examples. The density ratio of cones to rods ranges from 1:200 in the most nocturnal to 20:1 in a few diurnal species. In some species, the proportion of the spectral cone types and their distribution across the retina deviate from the pattern found in most mammals, including a complete absence of S-cones. Depending on species, the spectral sensitivity of the L-cone pigment may peak in the green, yellow, or orange, and that of the S-cone pigment in the blue, violet, or near-ultraviolet. While exclusive expression of one pigment per cone is the rule, some species feature coexpression of the L- and S-pigment in a significant proportion of their cones. It is widely assumed that all these variations represent adaptations to specific visual needs associated with particular habitats and lifestyles. However, in many cases we have not yet identified the adaptive value of a given photoreceptor arrangement. Comparative anatomy is a fruitful approach to explore the range of possible arrangements within the blueprint of the mammalian retina and to identify species with particularly interesting or puzzling patterns that deserve further scrutiny with physiological and behavioral assays. (c) 2005 Wiley-Liss, Inc.

The primary mammalian circadian clock resides in the suprachiasmatic nucleus (SCN), a recipient of dense retinohypothalamic innervation. In its most basic form, the circadian rhythm system is part of the greater visual system. A secondary component of the circadian visual system is the retinorecipient intergeniculate leaflet (IGL) which has connections to many parts of the brain, including efferents converging on targets of the SCN. The IGL also provides a major input to the SCN, with a third major SCN afferent projection arriving from the median raphe nucleus. The last decade has seen a blossoming of research into the anatomy and function of the visual, geniculohypothalamic and midbrain serotonergic systems modulating circadian rhythmicity in a variety of species. There has also been a substantial and simultaneous elaboration of knowledge about the intrinsic structure of the SCN. Many of the developments have been driven by molecular biological investigation of the circadian clock and the molecular tools are enabling novel understanding of regional function within the SCN. The present discussion is an extension of the material covered by the 1994 review, "The Circadian Visual System."