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      Long-Term Effects on Cardiac Output and Peripheral Resistance in Patients Treated with Enalapril after Acute Myocardial Infarction

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          In the Cooperative New Scandinavian Enalapril Survival Study (CONSENSUS II), in which enalapril treatment was initiated intravenously within 24 h after acute myocardial infarction, there was a neutral effect on 6-month mortality, whereas a beneficial effect on the progression of congestive heart failure was noted. We studied the effect of enalapril on left ventricular systolic function in terms of cardiac output and mean acceleration time measured by pulsed-wave Doppler in the left ventricular outflow tract and peripheral resistance. Early angiotensin-converting enzyme inhibition after acute myocardial infarction did not result in a general improvement of cardiac output. However, a small increase in cardiac output was observed in a subgroup of enalapril-treated patients with ejection fraction ≥45%, probably due to a reduction in peripheral resistance in these patients.

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          Most cited references 3

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          ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction

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            GISSI-3: effects of lisiriopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction

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              ACE inhibition in acute myocardial infarction.

               M Pfeffer (1995)

                Author and article information

                S. Karger AG
                May 1998
                29 October 2008
                : 89
                : 4
                : 291-296
                a Division of Internal Medicine, Danderyds Hospital, Danderyd, and Department of Cardiology, Thoracic Clinics, Karolinska Hospital, Stockholm, b Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden; c Cardiology Division, Department of Medicine, Central Hospital in Rogaland, Stavanger, Norway; d Cardiology Division, Department of Medicine, Rigshospitalet, University of Copenhagen, Denmark
                6807 Cardiology 1998;89:291–296
                © 1998 S. Karger AG, Basel

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                Page count
                Figures: 3, Tables: 4, References: 18, Pages: 6
                Coronary Care


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