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      Long-Term Effects on Cardiac Output and Peripheral Resistance in Patients Treated with Enalapril after Acute Myocardial Infarction

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          Abstract

          In the Cooperative New Scandinavian Enalapril Survival Study (CONSENSUS II), in which enalapril treatment was initiated intravenously within 24 h after acute myocardial infarction, there was a neutral effect on 6-month mortality, whereas a beneficial effect on the progression of congestive heart failure was noted. We studied the effect of enalapril on left ventricular systolic function in terms of cardiac output and mean acceleration time measured by pulsed-wave Doppler in the left ventricular outflow tract and peripheral resistance. Early angiotensin-converting enzyme inhibition after acute myocardial infarction did not result in a general improvement of cardiac output. However, a small increase in cardiac output was observed in a subgroup of enalapril-treated patients with ejection fraction ≥45%, probably due to a reduction in peripheral resistance in these patients.

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          Most cited references 3

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          ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction

            (1995)
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            GISSI-3: effects of lisiriopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction

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              ACE inhibition in acute myocardial infarction.

               M Pfeffer (1995)
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                Author and article information

                Journal
                CRD
                Cardiology
                10.1159/issn.0008-6312
                Cardiology
                S. Karger AG
                0008-6312
                1421-9751
                1998
                May 1998
                29 October 2008
                : 89
                : 4
                : 291-296
                Affiliations
                a Division of Internal Medicine, Danderyds Hospital, Danderyd, and Department of Cardiology, Thoracic Clinics, Karolinska Hospital, Stockholm, b Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden; c Cardiology Division, Department of Medicine, Central Hospital in Rogaland, Stavanger, Norway; d Cardiology Division, Department of Medicine, Rigshospitalet, University of Copenhagen, Denmark
                Article
                6807 Cardiology 1998;89:291–296
                10.1159/000006807
                9643277
                © 1998 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 3, Tables: 4, References: 18, Pages: 6
                Categories
                Coronary Care

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