Long-Term Effects on Cardiac Output and Peripheral Resistance in Patients Treated with Enalapril after Acute Myocardial Infarction

Abstract

In the Cooperative New Scandinavian Enalapril Survival Study (CONSENSUS II), in which enalapril treatment was initiated intravenously within 24 h after acute myocardial infarction, there was a neutral effect on 6-month mortality, whereas a beneficial effect on the progression of congestive heart failure was noted. We studied the effect of enalapril on left ventricular systolic function in terms of cardiac output and mean acceleration time measured by pulsed-wave Doppler in the left ventricular outflow tract and peripheral resistance. Early angiotensin-converting enzyme inhibition after acute myocardial infarction did not result in a general improvement of cardiac output. However, a small increase in cardiac output was observed in a subgroup of enalapril-treated patients with ejection fraction ≥45%, probably due to a reduction in peripheral resistance in these patients.

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1998

Publication date (Print): May 1998

Publication date (Electronic): 29 October 2008

Volume: 89

Issue: 4

Pages: 291-296

Affiliations

^a Division of Internal Medicine, Danderyds Hospital, Danderyd, and Department of Cardiology, Thoracic Clinics, Karolinska Hospital, Stockholm, ^b Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden; ^c Cardiology Division, Department of Medicine, Central Hospital in Rogaland, Stavanger, Norway; ^d Cardiology Division, Department of Medicine, Rigshospitalet, University of Copenhagen, Denmark

Article

Publisher ID: 6807 Other ID: Cardiology 1998;89:291–296

DOI: 10.1159/000006807

PubMed ID: 9643277

Copyright statement: © 1998 S. Karger AG, Basel

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Page count

Figures: 3, Tables: 4, References: 18, Pages: 6

Product

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Self URI (journal page): https://www.karger.com/SubjectArea/Cardiovascular-System

Categories

Subject: Coronary Care