Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial.

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Abstract

Aside from the multikinase inhibitor sorafenib, there are no effective systemic therapies for the treatment of advanced hepatocellular carcinoma.

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Journal

Journal ID (iso-abbrev): JAMA

Title: JAMA

Publisher: American Medical Association (AMA)

ISSN (Electronic): 1538-3598

ISSN (Print): 0098-7484

Publication date (Electronic): Jul 02 2014

Volume: 312

Issue: 1

Affiliations

[1 ] Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston.

[2 ] Kinki University School of Medicine, Osaka, Japan.

[3 ] ICM Val d'Aurelle, Montpellier, France.

[4 ] University Nord De France, Lille, France.

[5 ] Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

[6 ] Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

[7 ] University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

[8 ] Hôpital Saint André, Bordeaux, France.

[9 ] Medical School Hannover, Hannover, Germany.

[10 ] Kaohsiung Chang Gung Memorial Hospital, Taiwan.

[11 ] CHRU de Tours, Tours, France.

[12 ] Medical University of Vienna, Vienna, Austria.

[13 ] Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Italy.

[14 ] G Rummo Hospital, Benevento, Italy.

[15 ] Kyorin University School of Medicine, Tokyo, Japan.

[16 ] Novartis Pharma, Basel, Switzerland.

[17 ] Novartis Pharmaceuticals, East Hanover, New Jersey.

[18 ] National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan19National Cheng Kung University Hospital, Tainan, Taiwan20Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Article

Publisher Item ID: 1884577

DOI: 10.1001/jama.2014.7189

PubMed ID: 25058218

SO-VID: bf501be9-481d-411b-a099-9ec02937359f

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