Changes related to the natural CD3 ⁺, CD4 ⁺, CD8 ⁺ T cell counts among antiretroviral treatment - naive HIV/AIDS patients in Yuxi, Yunnan

Abstract

Objective To explore the HIV disease progression and the changes related to the natural CD3 ⁺, CD4 ⁺, CD8 ⁺ T cell counts among antiretroviral treatment - naive HIV/AIDS patients in Yuxi prefecture.

Methods The counts of CD3 ⁺, CD4 ⁺, CD8 ⁺ T cell were collected with retrospective study from 2006 to 2014. Difference and change rate of CD3 ⁺, CD4 ⁺, CD8 ⁺ T cell counts was calculated and described.

Results The mean natural change rates of CD3, CD4 and CD8 were 4.14/μL,- 2.13/μL and 7.57/μL, respectively. About 886 cases(62.66%) of the HIV/AIDS patients had deletions of CD4 ⁺T cell counts. The higher the primary CD4 ⁺ T cell counts was, the faster the decline of CD4 ⁺ T cell counts between the first and the last, while the lower the primary CD4 ⁺ T cell counts was, the slower the decline of CD4 ⁺T cell counts between the first and the last, there were of statistical significance ( P<0.05). Results from the statistical analysis indicated that male, the Han ethnicity, the people aged 50 or more, transmission mode was injecting drug using were significantly associated with the significant depletion of CD4 ⁺ T cell counts, while that female, minority, the people under the age of 50, transmission mode was sex were significantly associated with the significant uptrend of CD3 ⁺, CD8 ⁺T cell counts (all of P<0.05).

Conclusion The changing rate of CD3 ⁺, CD4 ⁺, CD8 ⁺T cell counts among ART- naive HIV infected patients in Yuxi prefecture was relatively slow. However, substantial proportion of them showed significant decreases of CD4 ⁺ T cell counts, or some of them showed significant increases of CD3 ⁺, CD8 ⁺T cell counts, which was determined by many factors, consistently follow-up those HIV infected patients were needed and the initiation of ART, if necessary.

Abstract

摘要： 目的 探讨玉溪市未抗病毒治疗HIV感染者/艾滋病患者 (HIV/AIDS) T 淋巴细胞计数 (CD3、CD4和CD8) 自 然变化, 了解其艾滋病自然病程。 方法 收集 2006—2014 年间玉溪市新报告 HIV/AIDS 未抗病毒治疗资料, 获取首次 与末次 CD3、CD4 和CD8数据, 描述并比较CD3、CD4和CD8自然变化速率。 结果 CD3、CD4和CD8月均自然变化速率 分别为 4.14个/μL、-2.13个/μL 和 7.57个/μL。其中 886 例 (62.66%) CD4 末次较首次低, 表现为自然下降。首次 CD4 越 高, 其月均下降越快, 而首次 CD4 较低, 其月均下降较慢甚至出现上升, 差异有统计学意义 ( P<0.05)。男性、汉族、≥50 岁 者、传播途径为注射吸毒者月均 CD4 自然变化下降速率较快, 而女性、少数民族、50 岁以下者、传播途径为性传播者 CD3、CD8 上升速率较快, 差异均有统计学意义 ( P 均<0.05)。 结论 玉溪市 HIV/AIDS CD3、CD4 和 CD8 自然变化总体平 缓, 但仍然有部分 HIV/AIDS 的 CD4 下降较快, 或是 CD3、CD8 上升较快, 需对该类人群加强随访, 及时介人抗病毒治疗。